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Who was studied 1,840 European ancestry cases, 5,163 European ancestry controls and (Liu et al); replicated in 620 European ancestry cases, 2,514 European ancestry controls.
The effect
Each copy of the T allele carried 1.34 times the odds of Primary biliary cholangitis (95% confidence interval 1.25-1.45); p = 2 × 10−14.
How common The T allele had a frequency of about 20% in the people studied.
Where it sits Chromosome 1, band 1q31.3 — between genes, 29.9 kb from DENND1B.
What each result means
C/CNo copy of the version the research linked to Primary biliary cholangitis. This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Primary biliary cholangitis. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Primary biliary cholangitis. That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature genetics · 2011 · PMID 21399635 · open access
Questions about rs12134279
What is rs12134279?
rs12134279 is a single position in the genome, in or near the DENND1B gene. Published research associates it with primary biliary cholangitis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs12134279 linked to?
On MyGeneLog this position is linked to Primary Biliary Cholangitis. The research behind each link, and its sources, are set out on that condition page.
Does having rs12134279 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs12134279 come from?
GWAS Catalog, Nat Genet 2011, PMID:21399635. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 412222223224Reads by AI crawlersClaude2ChatGPT2Google · Gemini0Perplexity2Meta AI2Microsoft · Copilot2Amazon2Apple3China (ByteDance, Huawei, Baidu…)2ByteDance (Doubao)2Others24Total41Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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