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Who was studied 38,000 South Asian ancestry individuals.
The effect
Each copy of the T allele shifted the measure 0.08 lower (95% confidence interval 0.062-0.098); p = 5 × 10−19.
Where it sits Chromosome 1, band 1q21.2 — in an intron of MCL1.
What each result means
C/CNo copy of the version the research linked to Monocyte count. This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Monocyte count. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Monocyte count. That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature communications · 2024 · PMID 39414775 · open access
Questions about rs12131809
What is rs12131809?
rs12131809 is a single position in the genome, in or near the MCL1 gene. Published research associates it with monocyte count. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs12131809 linked to?
On MyGeneLog this position is linked to Monocyte Count, Blood Cell Counts. The research behind each link, and its sources, are set out on that condition page.
Does having rs12131809 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs12131809 come from?
GWAS Catalog, Nature communications 2024, PMID:39414775. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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