G/GPublished research associates this genotype (two copies of the reported risk allele) with a higher likelihood of High myopia compared to the general population. (GWAS Catalog, Ophthalmology 2020, PMID:32428537)
G/TPublished research associates this genotype (one copy of the reported risk allele) with an intermediate association with High myopia. (GWAS Catalog, Ophthalmology 2020, PMID:32428537)
T/TPublished research associates this genotype with typical/baseline likelihood of High myopia — no copies of the reported risk allele. (GWAS Catalog, Ophthalmology 2020, PMID:32428537)
rs12032649 is a single position in the genome, in or near the ZC3H11B gene. Published research associates it with high myopia. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs12032649 linked to?
On MyGeneLog this position is linked to Myopia. The research behind each link, and its sources, are set out on that condition page.
Does having rs12032649 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs12032649 come from?
GWAS Catalog, Ophthalmology 2020, PMID:32428537. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.