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Who was studied up to 1,090 Southern European ancestry Crohn's disease cases; replicated in up to 1,296 Southern European ancestry Crohn's disease cases.
The effect
Each copy of the C allele carried 2.03 times the odds of Crohn's disease-related phenotypes (95% confidence interval 1.52-2.73); p = 5 × 10−7.
How common The C allele had a frequency of about 6% in the people studied.
Where it sits Chromosome 3, band 3p14.1 — in an intron of LOC107986018.
What each result means
C/CTwo copies of the version the research linked to Crohn's disease-related phenotypes. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/TOne copy of the version the research linked to Crohn's disease-related phenotypes. That is a smaller link than two copies.
T/TNo copy of the version the research linked to Crohn's disease-related phenotypes. This is the starting point the study compared everyone against.
rs11924265 is a single position in the genome, in or near the MAGI1 gene. Published research associates it with crohn's disease-related phenotypes. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs11924265 linked to?
On MyGeneLog this position is linked to Crohn's Disease. The research behind each link, and its sources, are set out on that condition page.
Does having rs11924265 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs11924265 come from?
GWAS Catalog, Gastroenterology 2014, PMID:25557950. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 47323110223219Reads by AI crawlersClaude3ChatGPT2Google · Gemini3Perplexity1Meta AI10Microsoft · Copilot2Amazon2Apple3China (ByteDance, Huawei, Baidu…)2ByteDance (Doubao)2Others19Total47Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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