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Fetal hemoglobin levels

BCL11A · rs11886868

Where this position leads

Condition: Blood Cell Counts

What the study found

Who was studied 4,305 European ancestry individuals; replicated in 521 European ancestry individuals.

The effect Each copy of the T allele shifted the measure 0.48 lower; p = 7 × 10⁻³⁵.

How common The T allele had a frequency of about 80% in the people studied.

Where it sits Chromosome 2, band 2p16.1 — in an intron of BCL11A.

What ClinVar records

Classification Benign for Fetal hemoglobin quantitative trait locus 5, Dias-Logan syndrome; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 6 submitters), last evaluated 2023-04-24. ClinVar record 127265 NM_022893.4(BCL11A):c.386-24278G>A

What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.

What each result means

C/C No copy of the version the research linked to Fetal hemoglobin levels. This is the starting point the study compared everyone against.

C/T One copy of the version the research linked to Fetal hemoglobin levels. That is a smaller link than two copies.

T/T Two copies of the version the research linked to Fetal hemoglobin levels. That is the strongest link of the three results. A link in a study is not a diagnosis.

Source

Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of beta-thalassemia

Uda M, Galanello R, Sanna S, Lettre G, Sankaran VG, Chen W, Usala G, Busonero F, Maschio A, Albai G, Piras MG, Sestu N

and 18 more — show all

Lai S, Dei M, Mulas A, Crisponi L, Naitza S, Asunis I, Deiana M, Nagaraja R, Perseu L, Satta S, Cipollina MD, Sollaino C, Moi P, Hirschhorn JN, Orkin SH, Abecasis GR, Schlessinger D, Cao A

Proceedings of the National Academy of Sciences of the United States of America · 2008 · PMID 18245381

Questions about rs11886868

What is rs11886868?

rs11886868 is a single position in the genome, in or near the BCL11A gene. Published research associates it with fetal hemoglobin levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs11886868 linked to?

On MyGeneLog this position is linked to Blood Cell Counts. The research behind each link, and its sources, are set out on that condition page.

Does having rs11886868 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs11886868 come from?

GWAS Catalog, Proc Natl Acad Sci U S A 2008, PMID:18245381. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Fetal hemoglobin levels (rs11886868). MyGeneLog™. https://www.mygenelog.com/variants/rs11886868

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