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Heart failure

near OR2A2 · rs117540300

Where this position leads

What the study found

Who was studied 5,791 African ancestry cases, 20,883 African ancestry controls, 1,170 American ancestry cases, 13,217 American ancestry controls, 95,524 European ancestry cases, 1,270,968 European ancestry controls, 17,718 East Asian ancestry cases, 247,144 East Asian ancestry controls.

The effect Each copy of the A allele shifted the measure 0.0997 higher (95% confidence interval 0.065-0.134); p = 1 × 10⁻⁸.

How common The A allele had a frequency of about 3% in the people studied.

Where it sits Chromosome 7, band 7q35 — between genes, 2.2 kb from OR2A15P.

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Heart failure compared to the general population.

A/C Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Heart failure.

C/C Published research associates this genotype with typical/baseline likelihood of Heart failure — no copies of the reported risk allele.

Source

Genome-wide analysis of heart failure yields insights into disease heterogeneity and enables prognostic prediction in the Japanese population

Enzan N, Miyazawa K, Koyama S, Kurosawa R, Ieki H, Yoshida H, Takechi F, Fukuyama M, Osako R, Tomizuka K, Liu X, Ozaki K

and 18 more — show all

Onouchi Y, Matsuda K, Momozawa Y, Aburatani H, Kamatani Y, Yamaguchi T, Akazawa H, Node K, Ellinor PT, Levin MG, Damrauer SM, Voight BF, Joseph J, Sun YV, Terao C, Ninomiya T, Komuro I, Ito K

BioBank Japan Project

Nature communications · 2025 · PMID 41184235 · open access

Questions about rs117540300

What is rs117540300?

rs117540300 is a single position in the genome, in or near the near OR2A2 gene. Published research associates it with heart failure. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs117540300 linked to?

On MyGeneLog this position is linked to Heart Failure Progression. The research behind each link, and its sources, are set out on that condition page.

Does having rs117540300 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs117540300 come from?

GWAS Catalog, Nature communications 2025, PMID:41184235. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Heart failure (rs117540300). MyGeneLog™. https://www.mygenelog.com/variants/rs117540300

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