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Medication use (antiglaucoma preparations and miotics)

MECOM · rs11709963

Where this position leads

Condition: Glaucoma

rs11709963 Condition: Glaucoma Glaucoma Condition rs11709963 rs11709963 MECOM

What the study found

Who was studied 5,215 European ancestry cases, 95,653 European ancestry controls.

The effect Each copy of the C allele shifted the measure 0.149 lower (95% confidence interval 0.095-0.202); p = 4 × 10−8.

How common The C allele had a frequency of about 16% in the people studied.

Where it sits Chromosome 3, band 3q26.2 — in an intron of MECOM.

What each result means

C/C Two copies of the version the research linked to Medication use (antiglaucoma preparations and miotics). That is the strongest link of the three results. A link in a study is not a diagnosis.
C/T One copy of the version the research linked to Medication use (antiglaucoma preparations and miotics). That is a smaller link than two copies.
T/T No copy of the version the research linked to Medication use (antiglaucoma preparations and miotics). This is the starting point the study compared everyone against.
Source

Questions about rs11709963

What is rs11709963?

rs11709963 is a single position in the genome, in or near the MECOM gene. Published research associates it with medication use (antiglaucoma preparations and miotics). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs11709963 linked to?

On MyGeneLog this position is linked to Glaucoma. The research behind each link, and its sources, are set out on that condition page.

Does having rs11709963 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs11709963 come from?

GWAS Catalog, Nat Commun 2019, PMID:31015401. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Medication use (antiglaucoma preparations and miotics) (rs11709963). MyGeneLog™. https://www.mygenelog.com/variants/rs11709963

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