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Metabolite levels

SLCO1B1 · rs116853509

Where this position leads

Condition: Blood Metabolite Levels

Drugs: Statins, Ticagrelor

rs116853509 Condition: Blood Metabolite Levels Blood Metabolite Levels Condition Drug: Statins Statins Drug Drug: Ticagrelor Ticagrelor Drug rs116853509 rs116853509 SLCO1B1

What the study found

Who was studied 1,954 Chinese ancestry individuals.

The effect Each copy of the T allele shifted the measure 0.24 higher (95% confidence interval 0.16-0.32); p = 4 × 10−10.

How common The T allele had a frequency of about 6% in the people studied.

Where it sits Chromosome 12, band 12p12.2 — in an intron of SLCO1B7.

What each result means

C/C Published research associates this genotype with typical/baseline likelihood of Metabolite levels — no copies of the reported risk allele.
C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Metabolite levels.
T/T Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Metabolite levels compared to the general population.
Source
Associations with metabolites in Chinese suggest new metabolic roles in Alzheimer's and Parkinson's diseases
Chai JF, Raichur S, Khor IW, Torta F, Chew WS, Herr DR, Ching J, Kovalik JP, Khoo CM, Wenk MR, Tai ES, Sim X
Human molecular genetics · 2020 · PMID 31628463

Questions about rs116853509

What is rs116853509?

rs116853509 is a single position in the genome, in or near the SLCO1B1 gene. Published research associates it with metabolite levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs116853509 linked to?

On MyGeneLog this position is linked to Blood Metabolite Levels. The research behind each link, and its sources, are set out on that condition page.

Does rs116853509 affect how medicines work?

SLCO1B1 carries pharmacogenomic findings for Statins, Ticagrelor. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.

Does having rs116853509 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs116853509 come from?

GWAS Catalog, Human molecular genetics 2020, PMID:31628463. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Metabolite levels (rs116853509). MyGeneLog™. https://www.mygenelog.com/variants/rs116853509

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