near CELF4 · rs11665070
Where this position leads
Condition: Depression (Self-Reported Symptoms)
Strength of the evidence
Its strongest genetic-study result is p = 10−9, with 9 associations in the GWAS Catalog.
4: ClinVar disease-causing, reviewed by an expert panel or a guideline (3–4 stars). 3: ClinVar, several labs agreeing (2 stars), or a genetic study at p ≤ 10−50. 2: ClinVar from one lab (1 star), or p ≤ 10−20. 1: ClinVar submitted without criteria (0 stars), or genome-wide significance (p ≤ 5×10−8). The higher of the two counts. It says how solid the evidence is, not whether it matters for a particular person.
What the study found
Who was studied 388,538 European ancestry individuals.
The effect Each copy of the A allele shifted the measure 0.0116 higher (95% confidence interval 0.0077-0.0155); p = 3 × 10−9.
How common The A allele had a frequency of about 67% in the people studied.
Where it sits Chromosome 18, band 18q12.2 — between genes, 5.9 kb from LOC124904288.
How common each version is
AG
A 67.7% · G 32.3%
A 68.3% · G 31.7%
A 69.2% · G 30.8%
A 70.2% · G 29.8%
A 67.8% · G 32.2%
A 52.8% · G 47.2%
A 48.7% · G 51.3%
A 49.8% · G 50.2%
The share of all copies of this position that are each version. Source: the population studies published in dbSNP (US NCBI); each row names its study.
rs11665070 is a single position in the genome, in or near the near CELF4 gene. Published research associates it with subjective well-being (mtag). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to Depression (Self-Reported Symptoms). The research behind each link, and its sources, are set out on that condition page.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Nat Genet 2018, PMID:29292387. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Subjective well-being (MTAG) (rs11665070). MyGeneLog™. https://www.mygenelog.com/variants/rs11665070