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Who was studied 36,614 Japanese ancestry cases, 155,150 Japanese ancestry controls.
The effect
The reported allele is A; the catalogue records no effect size
; p = 1 × 10−9.
How common The A allele had a frequency of about 6% in the people studied.
Where it sits Chromosome 11, band 11p15.5 — a synonymous change in ASCL2.
What each result means
A/ATwo copies of the version the research linked to Type 2 diabetes. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/GOne copy of the version the research linked to Type 2 diabetes. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Type 2 diabetes. This is the starting point the study compared everyone against.
rs116549635 is a single position in the genome, in or near the INS-IGF2 gene. Published research associates it with type 2 diabetes. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs116549635 linked to?
On MyGeneLog this position is linked to Type 2 Diabetes. The research behind each link, and its sources, are set out on that condition page.
Does having rs116549635 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs116549635 come from?
GWAS Catalog, Nature genetics 2019, PMID:30718926. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Type 2 diabetes (rs116549635). MyGeneLog™. https://www.mygenelog.com/variants/rs116549635