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Triglyceride to HDL cholesterol ratio

CETP · rs11644475

Where this position leads

What the study found

Who was studied 402,398 European ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.0633 higher (95% confidence interval 0.048-0.078); p = 3 × 10⁻¹¹.

How common The A allele had a frequency of about 97% in the people studied.

Where it sits Chromosome 16, band 16q13 — in an intron of CETP.

What ClinVar records

Classification Likely benign; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 2 submitters), last evaluated 2019-01-25. ClinVar record 1191702 NM_000078.3(CETP):c.930+230A>G

What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.

What each result means

A/A Two copies of the version the research linked to Triglyceride to HDL cholesterol ratio. That is the strongest link of the three results. A link in a study is not a diagnosis.

A/G One copy of the version the research linked to Triglyceride to HDL cholesterol ratio. That is a smaller link than two copies.

G/G No copy of the version the research linked to Triglyceride to HDL cholesterol ratio. This is the starting point the study compared everyone against.

Source

Comprehensive genetic study of the insulin resistance marker TG:HDL-C in the UK Biobank

Oliveri A, Rebernick RJ, Kuppa A, Pant A, Chen Y, Du X, Cushing KC, Bell HN, Raut C, Prabhu P, Chen VL, Halligan BD

and 1 more — show all

Speliotes EK

Nature genetics · 2024 · PMID 38200128

Questions about rs11644475

What is rs11644475?

rs11644475 is a single position in the genome, in or near the CETP gene. Published research associates it with triglyceride to hdl cholesterol ratio. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does rs11644475 affect how medicines work?

CETP carries pharmacogenomic findings for Statins. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.

Does having rs11644475 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs11644475 come from?

GWAS Catalog, Nature genetics 2024, PMID:38200128. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Triglyceride to HDL cholesterol ratio (rs11644475). MyGeneLog™. https://www.mygenelog.com/variants/rs11644475

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