NFKB2 · rs11574851
Where this position leads
Condition: Substance Use Disorder
What the study found
Who was studied 1,458,999 European ancestry individuals.
The effect Each copy of the T allele shifted the measure 5.45 higher; p = 5 × 10−8.
Where it sits Chromosome 10, band 10q24.32 — a synonymous change in NFKB2.
What ClinVar records
Classification
Benign/Likely benign for Immunodeficiency, common variable, 10; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 5 submitters), last evaluated 2026-02-04.
ClinVar record 474781 NM_001322934.2(NFKB2):c.2094C>T (p.Asn698=)
What this is ClinVar's aggregate record for this position (as of its 2026-09-24 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
rs11574851 is a single position in the genome, in or near the NFKB2 gene. Published research associates it with substance use disorder. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to Substance Use Disorder. The research behind each link, and its sources, are set out on that condition page.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Molecular psychiatry 2026, PMID:41057643. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Substance use disorder (rs11574851). MyGeneLog™. https://www.mygenelog.com/variants/rs11574851