Sensitive

Cancer

BRCA2 · rs11571833

Where this position leads

What the study found

Who was studied 5,020 European ancestry lung cancer cases, 3,718 European ancestry lung adenocarcinoma cases, 3,422 European ancestry lung squamous cell carcinoma cases, 15,414 European ancestry colorectal cancer cases, 10,809 European ancestry breast cancer cases, 4,939 European ancestry estrogen receptor negative breast cancer cases, 1,098 European ancestry ovarian cancer cases, 2,556 European ancestry serous ovarian cancer cases, 715 European ancestry ovarian endometrioid carcinoma cases, 9,710 European ancestry prostate cancer cases, 4,450 European ancestry aggressive prostate cancer cases, 61,820 European ancestry controls.

The effect Each copy of the T allele carried 1.60 times the odds of Cancer; p = 8 × 10⁻¹².

Where it sits Chromosome 13, band 13q13.1 — a stop-gain change in BRCA2.

What ClinVar records

Classification Benign for Breast-ovarian cancer, familial, susceptibility to, 2, Hereditary breast ovarian cancer syndrome, Hereditary cancer-predisposing syndrome, Breast and/or ovarian cancer, Malignant tumor of breast and 3 more; reviewed by expert panel (3 of 4 stars, 51 submitters), last evaluated 2024-06-11. ClinVar record 38266 NM_000059.4(BRCA2):c.9976A>T (p.Lys3326Ter)

What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.

What each result means

A/A No copy of the version the research linked to Cancer. This is the starting point the study compared everyone against.

A/T One copy of the version the research linked to Cancer. That is a smaller link than two copies.

T/T Two copies of the version the research linked to Cancer. That is the strongest link of the three results. A link in a study is not a diagnosis.

Source

Cross-Cancer Genome-Wide Analysis of Lung, Ovary, Breast, Prostate, and Colorectal Cancer Reveals Novel Pleiotropic Associations

Fehringer G, Kraft P, Pharoah PD, Eeles RA, Chatterjee N, Schumacher FR, Schildkraut JM, Lindström S, Brennan P, Bickeböller H, Houlston RS, Landi MT

and 121 more — show all

Caporaso N, Risch A, Amin Al Olama A, Berndt SI, Giovannucci EL, Grönberg H, Kote-Jarai Z, Ma J, Muir K, Stampfer MJ, Stevens VL, Wiklund F, Willett WC, Goode EL, Permuth JB, Risch HA, Reid BM, Bezieau S, Brenner H, Chan AT, Chang-Claude J, Hudson TJ, Kocarnik JK, Newcomb PA, Schoen RE, Slattery ML, White E, Adank MA, Ahsan H, Aittomäki K, Baglietto L, Blomquist C, Canzian F, Czene K, Dos-Santos-Silva I, Eliassen AH, Figueroa JD, Flesch-Janys D, Fletcher O, Garcia-Closas M, Gaudet MM, Johnson N, Hall P, Hazra A, Hein R, Hofman A, Hopper JL, Irwanto A, Johansson M, Kaaks R, Kibriya MG, Lichtner P, Liu J, Lund E, Makalic E, Meindl A, Müller-Myhsok B, Muranen TA, Nevanlinna H, Peeters PH, Peto J, Prentice RL, Rahman N, Sanchez MJ, Schmidt DF, Schmutzler RK, Southey MC, Tamimi R, Travis RC, Turnbull C, Uitterlinden AG, Wang Z, Whittemore AS, Yang XR, Zheng W, Zheng W, Buchanan DD, Casey G, Conti DV, Edlund CK, Gallinger S, Haile RW, Jenkins M, Le Marchand L, Li L, Lindor NM, Schmit SL, Thibodeau SN, Woods MO, Rafnar T, Gudmundsson J, Stacey SN, Stefansson K, Sulem P, Chen YA, Tyrer JP, Christiani DC, Wei Y, Shen H, Hu Z, Shu XO, Shiraishi K, Takahashi A, Bossé Y, Obeidat M, Nickle D, Timens W, Freedman ML, Li Q, Seminara D, Chanock SJ, Gong J, Peters U, Gruber SB, Amos CI, Sellers TA, Easton DF, Hunter DJ, Haiman CA, Henderson BE, Hung RJ

Ovarian Cancer Association Consortium (OCAC) · PRACTICAL Consortium · Hereditary Breast and Ovarian Cancer Research Group Netherlands (HEBON) · Colorectal Transdisciplinary (CORECT) Study · African American Breast Cancer Consortium (AABC) and African Ancestry Prostate Cancer Consortium (AAPC)

Cancer research · 2016 · PMID 27197191

What people read about alongside this

Fertility1

Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.

Questions about rs11571833

What is rs11571833?

rs11571833 is a single position in the genome, in or near the BRCA2 gene. Published research associates it with cancer. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs11571833 linked to?

On MyGeneLog this position is linked to Colorectal Cancer. The research behind each link, and its sources, are set out on that condition page.

What do people read about alongside rs11571833?

Subjects that appear in the title or abstract of the same papers as this rsID include fertility (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.

Does having rs11571833 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs11571833 come from?

GWAS Catalog, Cancer Res 2016, PMID:27197191. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Cancer (rs11571833). MyGeneLog™. https://www.mygenelog.com/variants/rs11571833

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