Sensitive

Lung cancer or family history of lung cancer

BRCA2 · rs11571815

Where this position leads

Condition: Lung Cancer

rs11571815 Condition: Lung Cancer Lung Cancer Condition rs11571815 rs11571815 BRCA2

What the study found

Who was studied 29,266 European ancestry lung cancer cases, 48,843 European ancestry individuals with family history of lung cancer, 251,837 European ancestry controls.

The effect Each copy of the A allele carried 1.70 times the odds of Lung cancer or family history of lung cancer (95% confidence interval 1.607-1.783); p = 7 × 10−32.

How common The A allele had a frequency of about 1% in the people studied.

Where it sits Chromosome 13, band 13q13.1 — in an intron of BRCA2.

What ClinVar records

Classification Benign for Breast-ovarian cancer, familial, susceptibility to, 2; reviewed by expert panel (3 of 4 stars, 2 submitters), last evaluated 2015-01-12. ClinVar record 209908 NM_000059.4(BRCA2):c.9257-276G>A

What this is ClinVar's aggregate record for this position (as of its 2026-10-12 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.

What each result means

A/A Two copies of the version the research linked to Lung cancer or family history of lung cancer. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to Lung cancer or family history of lung cancer. That is a smaller link than two copies.
G/G No copy of the version the research linked to Lung cancer or family history of lung cancer. This is the starting point the study compared everyone against.
Source

Questions about rs11571815

What is rs11571815?

rs11571815 is a single position in the genome, in or near the BRCA2 gene. Published research associates it with lung cancer or family history of lung cancer. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs11571815 linked to?

On MyGeneLog this position is linked to Lung Cancer. The research behind each link, and its sources, are set out on that condition page.

Does having rs11571815 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs11571815 come from?

GWAS Catalog, Journal of the National Cancer Institute 2022, PMID:35511172. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Lung cancer or family history of lung cancer (rs11571815). MyGeneLog™. https://www.mygenelog.com/variants/rs11571815

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