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X-21470 levels

SLCO1B1 · rs11519273

Where this position leads

Drugs: Statins, Ticagrelor

rs11519273 Drug: Statins Statins Drug Drug: Ticagrelor Ticagrelor Drug rs11519273 rs11519273 SLCO1B1

What the study found

Who was studied 7,700 European ancestry individuals.

The effect Each copy of the T allele shifted the measure 0.225 higher (95% confidence interval 0.18-0.27); p = 1 × 10−27.

How common The T allele had a frequency of about 17% in the people studied.

Where it sits Chromosome 12, band 12p12.1 — in an intron of SLCO1B1.

What each result means

C/C No copy of the version the research linked to X-21470 levels. This is the starting point the study compared everyone against.
C/T One copy of the version the research linked to X-21470 levels. That is a smaller link than two copies.
T/T Two copies of the version the research linked to X-21470 levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
Source

Questions about rs11519273

What is rs11519273?

rs11519273 is a single position in the genome, in or near the SLCO1B1 gene. Published research associates it with x-21470 levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does rs11519273 affect how medicines work?

SLCO1B1 carries pharmacogenomic findings for Statins, Ticagrelor. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.

Does having rs11519273 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs11519273 come from?

GWAS Catalog, Nature genetics 2023, PMID:36635386. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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X-21470 levels (rs11519273). MyGeneLog™. https://www.mygenelog.com/variants/rs11519273

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