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Who was studied 275 Korean ancestry cases, 2,369 Korean ancestry controls; replicated in 242 Korean ancestry cases, 1,066 Korean ancestry controls.
The effect
Each copy of the C allele carried 2.25 times the odds of Crohn's disease (95% confidence interval 1.91-2.66); p = 9 × 10−23.
How common The C allele had a frequency of about 12% in the people studied.
Where it sits Chromosome 6, band 6p21.33 — in an intron of LOC112267902.
What each result means
C/CTwo copies of the version the research linked to Crohn's disease. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/TOne copy of the version the research linked to Crohn's disease. That is a smaller link than two copies.
T/TNo copy of the version the research linked to Crohn's disease. This is the starting point the study compared everyone against.
rs114985235 is a single position in the genome, in or near the HLA-B gene. Published research associates it with crohn's disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs114985235 linked to?
On MyGeneLog this position is linked to Crohn's Disease. The research behind each link, and its sources, are set out on that condition page.
Does rs114985235 affect how medicines work?
HLA-B carries pharmacogenomic findings for Abacavir, Allopurinol, Carbamazepine and oxcarbazepine. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.
Does having rs114985235 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs114985235 come from?
GWAS Catalog, Inflamm Bowel Dis 2016, PMID:26891255. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
1 5132247222225Reads by AI crawlersClaude3ChatGPT2Google · Gemini2Perplexity4Meta AI7Microsoft · Copilot2Amazon2Apple2China (ByteDance, Huawei, Baidu…)2ByteDance (Doubao)2Others25Total51Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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