0 110Reads by AI crawlersClaude1ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon0Apple0China (ByteDance, Huawei, Baidu…)0Others0Total1Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Who was studied 13,530 European ancestry cases, 454,945 European ancestry controls, 4,017 East Asian ancestry cases, 162,653 East Asian ancestry controls.
The effect
Each copy of the T allele shifted the measure 0.212 higher (95% confidence interval 0.14-0.28); p = 9 × 10−9.
Where it sits Chromosome 1, band 1p21.3 — in an intron of DPYD.
What each result means
C/CNo copy of the version the research linked to Chronic obstructive pulmonary disease. This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Chronic obstructive pulmonary disease. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Chronic obstructive pulmonary disease. That is the strongest link of the three results. A link in a study is not a diagnosis.
rs114904431 is a single position in the genome, in or near the DPYD gene. Published research associates it with chronic obstructive pulmonary disease. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs114904431 linked to?
On MyGeneLog this position is linked to Chronic Obstructive Pulmonary Disease (COPD). The research behind each link, and its sources, are set out on that condition page.
Does rs114904431 affect how medicines work?
DPYD carries pharmacogenomic findings for Fluoropyrimidines. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.
Does having rs114904431 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs114904431 come from?
GWAS Catalog, Nature genetics 2021, PMID:34594039. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 110Reads by AI crawlersClaude1ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon0Apple0China (ByteDance, Huawei, Baidu…)0Others0Total1Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.