Sensitive

Kidney cancer

near LINC02952 · rs11263445

Where this position leads

What the study found

Who was studied 25,890 European ancestry cases, 743,585 European ancestry controls, 897 African American or Afro-Caribbean cases, 3,109 African American or Afro-Caribbean controls, 1,612 Hispanic or Latin American cases, 2,180 Hispanic or Latin American controls, 621 East Asian ancestry cases, 86,796 East Asian ancestry controls.

The effect Each copy of the C allele carried 1.11 times the odds of Kidney cancer (95% confidence interval 1.08-1.15); p = 1 × 10⁻¹⁰.

How common The C allele had a frequency of about 12% in the people studied.

Where it sits Chromosome 11, band 11q13.3 — between genes, 0.3 kb from LINC02952.

What each result means

C/C Two copies of the version the research linked to Kidney cancer. That is the strongest link of the three results. A link in a study is not a diagnosis.

C/T One copy of the version the research linked to Kidney cancer. That is a smaller link than two copies.

T/T No copy of the version the research linked to Kidney cancer. This is the starting point the study compared everyone against.

Source

Multi-ancestry genome-wide association study of kidney cancer identifies 63 susceptibility regions

Purdue MP, Dutta D, Machiela MJ, Gorman BR, Winter T, Okuhara D, Cleland S, Ferreiro-Iglesias A, Scheet P, Liu A, Wu C, Antwi SO

and 120 more — show all

Larkin J, Zequi SC, Sun M, Hikino K, Hajiran A, Lawson KA, Cárcano F, Blanchet O, Shuch B, Nepple KG, Margue G, Sundi D, Diver WR, Folgueira MAAK, van Bokhoven A, Neffa F, Brown KM, Hofmann JN, Rhee J, Yeager M, Cole NR, Hicks BD, Manning MR, Hutchinson AA, Rothman N, Huang WY, Linehan WM, Lori A, Ferragu M, Zidane-Marinnes M, Serrano SV, Magnabosco WJ, Vilas A, Decia R, Carusso F, Graham LS, Anderson K, Bilen MA, Arciero C, Pellegrin I, Ricard S, Scelo G, Banks RE, Vasudev NS, Soomro N, Stewart GD, Adeyoju A, Bromage S, Hrouda D, Gibbons N, Patel P, Sullivan M, Protheroe A, Nugent FI, Fournier MJ, Zhang X, Martin LJ, Komisarenko M, Eisen T, Cunningham SA, Connolly DC, Uzzo RG, Zaridze D, Mukeria A, Holcatova I, Hornakova A, Foretova L, Janout V, Mates D, Jinga V, Rascu S, Mijuskovic M, Savic S, Milosavljevic S, Gaborieau V, Abedi-Ardekani B, McKay J, Johansson M, Phouthavongsy L, Hayman L, Li J, Lungu I, Bezerra SM, Souza AG, Sares CTG, Reis RB, Gallucci FP, Cordeiro MD, Pomerantz M, Lee GM, Freedman ML, Jeong A, Greenberg SE, Sanchez A, Thompson RH, Sharma V, Thiel DD, Ball CT, Abreu D, Lam ET, Nahas WC, Master VA, Patel AV, Bernhard JC, Freedman ND, Bigot P, Reis RM, Colli LM, Finelli A, Manley BJ, Terao C, Choueiri TK, Carraro DM, Houlston R, Eckel-Passow JE, Abbosh PH, Ganna A, Brennan P, Gu J, Chanock SJ

BioBank Japan Project · FinnGen

Nature genetics · 2024 · PMID 38671320

Questions about rs11263445

What is rs11263445?

rs11263445 is a single position in the genome, in or near the near LINC02952 gene. Published research associates it with kidney cancer. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs11263445 linked to?

On MyGeneLog this position is linked to Renal Cell Carcinoma. The research behind each link, and its sources, are set out on that condition page.

Does having rs11263445 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs11263445 come from?

GWAS Catalog, Nature genetics 2024, PMID:38671320. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Kidney cancer (rs11263445). MyGeneLog™. https://www.mygenelog.com/variants/rs11263445

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