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Primary open angle glaucoma (PheCode 365.11)

ARHGAP20 · rs11213533

Where this position leads

Condition: Glaucoma

rs11213533 Condition: Glaucoma Glaucoma Condition rs11213533 rs11213533 ARHGAP20

What the study found

Who was studied 13,552 African American or Afro-Caribbean cases, 105,042 African American or Afro-Caribbean controls, 2,857 Hispanic or Latin American cases, 56,071 Hispanic or Latin American controls, 312 East Asian ancestry cases, 6,452 East Asian ancestry controls, 20,091 European ancestry cases, 424,364 European ancestry controls.

The effect Each copy of the G allele shifted the measure 0.0972 higher (95% confidence interval 0.066-0.128); p = 2 × 10−11.

How common The G allele had a frequency of about 91% in the people studied.

Where it sits Chromosome 11, band 11q23.1 — in an intron of ARHGAP20.

What each result means

A/A No copy of the version the research linked to Primary open angle glaucoma (PheCode 365.11). This is the starting point the study compared everyone against.
A/G One copy of the version the research linked to Primary open angle glaucoma (PheCode 365.11). That is a smaller link than two copies.
G/G Two copies of the version the research linked to Primary open angle glaucoma (PheCode 365.11). That is the strongest link of the three results. A link in a study is not a diagnosis.
Source
Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program
Verma A, Huffman JE, Rodriguez A, Conery M, Liu M, Ho YL, Kim Y, Heise DA, Guare L, Panickan VA, Garcon H, Linares F
and 59 more — show all
Costa L, Goethert I, Tipton R, Honerlaw J, Davies L, Whitbourne S, Cohen J, Posner DC, Sangar R, Murray M, Wang X, Dochtermann DR, Devineni P, Shi Y, Nandi TN, Assimes TL, Brunette CA, Carroll RJ, Clifford R, Duvall S, Gelernter J, Hung A, Iyengar SK, Joseph J, Kember R, Kranzler H, Kripke CM, Levey D, Luoh SW, Merritt VC, Overstreet C, Deak JD, Grant SFA, Polimanti R, Roussos P, Shakt G, Sun YV, Tsao N, Venkatesh S, Voloudakis G, Justice A, Begoli E, Ramoni R, Tourassi G, Pyarajan S, Tsao P, O'Donnell CJ, Muralidhar S, Moser J, Casas JP, Bick AG, Zhou W, Cai T, Voight BF, Cho K, Gaziano JM, Madduri RK, Damrauer S, Liao KP
Science (New York, N.Y.) · 2024 · PMID 39024449 · open access

Questions about rs11213533

What is rs11213533?

rs11213533 is a single position in the genome, in or near the ARHGAP20 gene. Published research associates it with primary open angle glaucoma (phecode 365.11). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs11213533 linked to?

On MyGeneLog this position is linked to Glaucoma. The research behind each link, and its sources, are set out on that condition page.

Does having rs11213533 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs11213533 come from?

GWAS Catalog, Science (New York, N.Y.) 2024, PMID:39024449. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Primary open angle glaucoma (PheCode 365.11) (rs11213533). MyGeneLog™. https://www.mygenelog.com/variants/rs11213533

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