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Intelligence

ESRRG · rs11117646

Where this position leads

What each result means

A/A Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Intelligence compared to the general population.

A/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Intelligence.

T/T Published research associates this genotype with typical/baseline likelihood of Intelligence — no copies of the reported risk allele.

Source

Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence

Savage JE, Jansen PR, Stringer S, Watanabe K, Bryois J, de Leeuw CA, Nagel M, Awasthi S, Barr PB, Coleman JRI, Grasby KL, Hammerschlag AR

and 105 more — show all

Kaminski JA, Karlsson R, Krapohl E, Lam M, Nygaard M, Reynolds CA, Trampush JW, Young H, Zabaneh D, Hägg S, Hansell NK, Karlsson IK, Linnarsson S, Montgomery GW, Muñoz-Manchado AB, Quinlan EB, Schumann G, Skene NG, Webb BT, White T, Arking DE, Avramopoulos D, Bilder RM, Bitsios P, Burdick KE, Cannon TD, Chiba-Falek O, Christoforou A, Cirulli ET, Congdon E, Corvin A, Davies G, Deary IJ, DeRosse P, Dickinson D, Djurovic S, Donohoe G, Conley ED, Eriksson JG, Espeseth T, Freimer NA, Giakoumaki S, Giegling I, Gill M, Glahn DC, Hariri AR, Hatzimanolis A, Keller MC, Knowles E, Koltai D, Konte B, Lahti J, Le Hellard S, Lencz T, Liewald DC, London E, Lundervold AJ, Malhotra AK, Melle I, Morris D, Need AC, Ollier W, Palotie A, Payton A, Pendleton N, Poldrack RA, Räikkönen K, Reinvang I, Roussos P, Rujescu D, Sabb FW, Scult MA, Smeland OB, Smyrnis N, Starr JM, Steen VM, Stefanis NC, Straub RE, Sundet K, Tiemeier H, Voineskos AN, Weinberger DR, Widen E, Yu J, Abecasis G, Andreassen OA, Breen G, Christiansen L, Debrabant B, Dick DM, Heinz A, Hjerling-Leffler J, Ikram MA, Kendler KS, Martin NG, Medland SE, Pedersen NL, Plomin R, Polderman TJC, Ripke S, van der Sluis S, Sullivan PF, Vrieze SI, Wright MJ, Posthuma D

Nature genetics · 2018 · PMID 29942086

Questions about rs11117646

What is rs11117646?

rs11117646 is a single position in the genome, in or near the ESRRG gene. Published research associates it with intelligence. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs11117646 linked to?

On MyGeneLog this position is linked to Intelligence. The research behind each link, and its sources, are set out on that condition page.

Does having rs11117646 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs11117646 come from?

GWAS Catalog, Nat Genet 2018, PMID:29942086. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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