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Who was studied 14,296 European ancestry individuals; replicated in 5,698 European ancestry individuals.
The effect
Each copy of the A allele shifted the measure 0.177 lower (95% confidence interval 0.15-0.2); p = 7 × 10−37.
How common The A allele had a frequency of about 84% in the people studied.
Where it sits Chromosome 12, band 12p12.1 — in an intron of SLCO1B1.
What each result means
A/ATwo copies of the version the research linked to Pregnen-diol disulfate levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/COne copy of the version the research linked to Pregnen-diol disulfate levels. That is a smaller link than two copies.
C/CNo copy of the version the research linked to Pregnen-diol disulfate levels. This is the starting point the study compared everyone against.
Nature medicine · 2022 · PMID 36357675 · open access
Questions about rs11045866
What is rs11045866?
rs11045866 is a single position in the genome, in or near the SLCO1B1 gene. Published research associates it with pregnen-diol disulfate levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does rs11045866 affect how medicines work?
SLCO1B1 carries pharmacogenomic findings for Statins, Ticagrelor. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.
Does having rs11045866 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs11045866 come from?
GWAS Catalog, Nature medicine 2022, PMID:36357675. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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