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MEGF9 protein levels

SLCO1B1 · rs11045818

Where this position leads

Condition: Celiac Disease

Drugs: Statins, Ticagrelor

rs11045818 Condition: Celiac Disease Celiac Disease Condition Drug: Statins Statins Drug Drug: Ticagrelor Ticagrelor Drug rs11045818 rs11045818 SLCO1B1

What the study found

Who was studied 47,745 European ancestry individuals.

The effect Each copy of the A allele shifted the measure 0.122 higher (95% confidence interval 0.11-0.14); p = 5 × 10−67.

How common The A allele had a frequency of about 16% in the people studied.

Where it sits Chromosome 12, band 12p12.1 — a synonymous change in SLCO1B1.

What ClinVar records

Classification Benign for Rotor syndrome, SLCO1B1-related disorder; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 5 submitters), last evaluated 2025-07-24. ClinVar record 307936 NM_006446.5(SLCO1B1):c.411G>A (p.Ser137=)

What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.

What each result means

A/A Two copies of the version the research linked to MEGF9 protein levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
A/G One copy of the version the research linked to MEGF9 protein levels. That is a smaller link than two copies.
G/G No copy of the version the research linked to MEGF9 protein levels. This is the starting point the study compared everyone against.
Source
A scalable variational inference approach for increased mixed-model association power
Loya H, Kalantzis G, Cooper F, Palamara PF
Nature genetics · 2025 · PMID 39789286 · open access

Questions about rs11045818

What is rs11045818?

rs11045818 is a single position in the genome, in or near the SLCO1B1 gene. Published research associates it with megf9 protein levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs11045818 linked to?

On MyGeneLog this position is linked to Celiac Disease. The research behind each link, and its sources, are set out on that condition page.

Does rs11045818 affect how medicines work?

SLCO1B1 carries pharmacogenomic findings for Statins, Ticagrelor. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.

Does having rs11045818 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs11045818 come from?

GWAS Catalog, Nature genetics 2025, PMID:39789286. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

MEGF9 protein levels (rs11045818). MyGeneLog™. https://www.mygenelog.com/variants/rs11045818

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