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Who was studied 148,726 European ancestry cases, 24,646 African American cases, 8,616 Hispanic cases, 46,511 Asian ancestry cases, 965,732 European ancestry controls, 31,446 African American controls, 11,829 Hispanic controls, 169,776 Asian ancestry controls.
The effect
Each copy of the G allele shifted the measure 0.0308 lower (95% confidence interval 0.023-0.038); p = 1 × 10−15.
How common The G allele had a frequency of about 52% in the people studied.
Where it sits Chromosome 10, band 10q21.3 — in an intron of TET1.
What each result means
A/ANo copy of the version the research linked to Type 2 diabetes. This is the starting point the study compared everyone against.
A/GOne copy of the version the research linked to Type 2 diabetes. That is a smaller link than two copies.
G/GTwo copies of the version the research linked to Type 2 diabetes. That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature genetics · 2020 · PMID 32541925 · open access
Questions about rs10998338
What is rs10998338?
rs10998338 is a single position in the genome, in or near the TET1 gene. Published research associates it with type 2 diabetes. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs10998338 linked to?
On MyGeneLog this position is linked to Type 2 Diabetes. The research behind each link, and its sources, are set out on that condition page.
Does having rs10998338 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs10998338 come from?
GWAS Catalog, Nature genetics 2020, PMID:32541925. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Type 2 diabetes (rs10998338). MyGeneLog™. https://www.mygenelog.com/variants/rs10998338