Erythrocyte methylated 6-mercaptopurine metabolite concentration in 6-mercaptopurine-treated acute lymphoblastic leukaemia
TPMT · rs10949482
3 4332115123223Reads by AI crawlersClaude3ChatGPT2Google · Gemini1Perplexity1Meta AI5Microsoft · Copilot1Amazon2Apple3China (ByteDance, Huawei, Baidu…)2ByteDance (Doubao)2Others23Total43Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Who was studied up to 454 European ancestry individuals.
The effect
The reported allele is T; the catalogue records no effect size
; p = 1 × 10−20.
Where it sits Chromosome 6, band 6p22.3 — in the 3′ untranslated region of NHLRC1.
What ClinVar records
ClassificationBenign for Lafora disease; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 2 submitters), last evaluated 2018-06-14.
ClinVar record 356069NM_198586.3(NHLRC1):c.*336G>A
What this is ClinVar's aggregate record for this position (as of its 2026-10-19 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
What each result means
C/CNo copy of the version the research linked to Erythrocyte methylated 6-mercaptopurine metabolite concentration in 6-mercaptopurine-treated acute lymphoblastic leukaemia. This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Erythrocyte methylated 6-mercaptopurine metabolite concentration in 6-mercaptopurine-treated acute lymphoblastic leukaemia. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Erythrocyte methylated 6-mercaptopurine metabolite concentration in 6-mercaptopurine-treated acute lymphoblastic leukaemia. That is the strongest link of the three results. A link in a study is not a diagnosis.
rs10949482 is a single position in the genome, in or near the TPMT gene. Published research associates it with erythrocyte methylated 6-mercaptopurine metabolite concentration in 6-mercaptopurine-treated acute lymphoblastic leukaemia. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does rs10949482 affect how medicines work?
TPMT carries pharmacogenomic findings for Thiopurines. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.
Does having rs10949482 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs10949482 come from?
GWAS Catalog, Leukemia 2018, PMID:30201983. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
3 4332115123223Reads by AI crawlersClaude3ChatGPT2Google · Gemini1Perplexity1Meta AI5Microsoft · Copilot1Amazon2Apple3China (ByteDance, Huawei, Baidu…)2ByteDance (Doubao)2Others23Total43Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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