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Erythrocyte methylated 6-mercaptopurine metabolite concentration in 6-mercaptopurine-treated acute lymphoblastic leukaemia

TPMT · rs10949482

Where this position leads

Drug: Thiopurines

rs10949482 Drug: Thiopurines Thiopurines Drug rs10949482 rs10949482 TPMT

What each result means

C/C Published research associates this genotype with typical/baseline likelihood of Erythrocyte methylated 6-mercaptopurine metabolite concentration in 6-mercaptopurine-treated acute lymphoblastic leukaemia — no copies of the reported risk allele. (GWAS Catalog, Leukemia 2018, PMID:30201983)
C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Erythrocyte methylated 6-mercaptopurine metabolite concentration in 6-mercaptopurine-treated acute lymphoblastic leukaemia. (GWAS Catalog, Leukemia 2018, PMID:30201983)
T/T Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Erythrocyte methylated 6-mercaptopurine metabolite concentration in 6-mercaptopurine-treated acute lymphoblastic leukaemia compared to the general population. (GWAS Catalog, Leukemia 2018, PMID:30201983)

Source: GWAS Catalog, Leukemia 2018, PMID:30201983

Questions about rs10949482

What is rs10949482?

rs10949482 is a single position in the genome, in or near the TPMT gene. Published research associates it with erythrocyte methylated 6-mercaptopurine metabolite concentration in 6-mercaptopurine-treated acute lymphoblastic leukaemia. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does rs10949482 affect how medicines work?

TPMT carries pharmacogenomic findings for Thiopurines. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.

Does having rs10949482 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs10949482 come from?

GWAS Catalog, Leukemia 2018, PMID:30201983. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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