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Who was studied 23,963 European ancestry cases, 306,942 European ancestry controls, 6,935 East Asian ancestry cases, 39,588 East Asian ancestry controls, 3,281 Sub-Saharan African ancestry cases, 2,791 Sub-Saharan African ancestry controls; replicated in 43,254 European ancestry cases, 1,471,118 European ancestry controls.
The effect
Each copy of the T allele shifted the measure 0.0436 higher; p = 1 × 10−9.
Where it sits Chromosome 10, band 10q23.33 — between genes, 37.5 kb from XRCC6P1.
What each result means
C/CNo copy of the version the research linked to Glaucoma (primary open-angle). This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Glaucoma (primary open-angle). That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Glaucoma (primary open-angle). That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature communications · 2021 · PMID 33627673 · open access
Questions about rs10882167
What is rs10882167?
rs10882167 is a single position in the genome, in or near the CYP26A1 gene. Published research associates it with glaucoma (primary open-angle). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs10882167 linked to?
On MyGeneLog this position is linked to Glaucoma. The research behind each link, and its sources, are set out on that condition page.
Does having rs10882167 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs10882167 come from?
GWAS Catalog, Nature communications 2021, PMID:33627673. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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