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Who was studied 5,355 Icelandic ancestry individuals.
The effect
Each copy of the C allele shifted the measure 0.161 higher (95% confidence interval 0.13-0.2); p = 2 × 10−18.
How common The C allele had a frequency of about 49% in the people studied.
Where it sits Chromosome 1, band 1q24.2 — in an intron of F5.
What each result means
A/ANo copy of the version the research linked to Serum levels of protein CDH7. This is the starting point the study compared everyone against.
A/COne copy of the version the research linked to Serum levels of protein CDH7. That is a smaller link than two copies.
C/CTwo copies of the version the research linked to Serum levels of protein CDH7. That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature communications · 2022 · PMID 35078996 · open access
Questions about rs10800457
What is rs10800457?
rs10800457 is a single position in the genome, in or near the F5 gene. Published research associates it with serum levels of protein cdh7. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does rs10800457 affect how medicines work?
F5 carries pharmacogenomic findings for Combined hormonal contraceptives. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.
Does having rs10800457 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs10800457 come from?
GWAS Catalog, Nature communications 2022, PMID:35078996. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 201123211Reads by AI crawlersClaude1ChatGPT0Google · Gemini0Perplexity1Meta AI0Microsoft · Copilot0Amazon2Apple3China (ByteDance, Huawei, Baidu…)2ByteDance (Doubao)2Others11Total20Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Serum levels of protein CDH7 (rs10800457). MyGeneLog™. https://www.mygenelog.com/variants/rs10800457