CFH · rs1061170
Where this position leads
Condition: Age-Related Macular Degeneration
Supplement: AREDS2 Eye Formula
2021-07-29 · Hospital Clínic de Barcelona & IDIBAPS (Dr. Blanca Molins, Ocular Inflammation research group)
Complement Factor H (CFH) may be involved in age-related macular degeneration (AMD)
Barcelona researchers described how the CFH Y402H risk variant (rs1061170, profiled on this site) changes how well complement factor H regulates inflammation and oxidative stress in the retina, and how a separate protein, FHR4 (made from the related CFHR4 gene), can compete with CFH and blunt its protective effect -- a mechanistic explanation for why this one variant carries such a large share of AMD risk. This is an older finding (2021), included here because the date is accurate and the mechanism it describes is still the current explanation, not because it is recent.
rs1061170 is a single position in the genome, in or near the CFH gene. Published research associates it with age-related macular degeneration. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to Age-Related Macular Degeneration. The research behind each link, and its sources, are set out on that condition page.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Zareparsi et al. 2005, American Journal of Human Genetics — strong association of the Y402H variant in complement factor H with AMD. PMID 15895326. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.