MYBPC3 · rs1052373
Where this position leads
Condition: Age-Related Macular Degeneration
What the study found
Who was studied 98,316 European ancestry individuals.
The effect Each copy of the T allele shifted the measure 0.0915 higher (95% confidence interval 0.067-0.116); p = 8 × 10−14.
How common The T allele had a frequency of about 32% in the people studied.
Where it sits Chromosome 11, band 11p11.2 — a synonymous change in MYBPC3.
What ClinVar records
Classification
Benign for Cardiovascular phenotype, Left ventricular noncompaction 10, Hypertrophic cardiomyopathy, Hypertrophic cardiomyopathy 4, Cardiomyopathy; criteria provided, multiple submitters, no conflicts (2 of 4 stars, 19 submitters), last evaluated 2026-02-04.
ClinVar record 42700 NM_000256.3(MYBPC3):c.3288G>A (p.Glu1096=)
What this is ClinVar's aggregate record for this position (as of its 2026-09-24 release), not a result about you. A classification describes the variant against the condition named, as laboratories submitted it. Whether a person carries this variant, and what that would mean for them, is a question for a clinical test and a genetic counsellor.
rs1052373 is a single position in the genome, in or near the MYBPC3 gene. Published research associates it with cholesteryl esters to total lipids in large hdl percentage. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
On MyGeneLog this position is linked to Age-Related Macular Degeneration. The research behind each link, and its sources, are set out on that condition page.
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
GWAS Catalog, Ophthalmology science 2024, PMID:39091897. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Cholesteryl Esters to Total Lipids in Large HDL percentage (rs1052373). MyGeneLog™. https://www.mygenelog.com/variants/rs1052373