G/TCarries one copy of the T (Ser69) risk allele in ARMS2, a locus that contributes to AMD risk independently of the separate CFH gene.
T/TCarries two copies of the T (Ser69) risk allele. The discovery study found this locus acts additively with CFH: people homozygous for the risk allele at both ARMS2 and CFH had a disease odds ratio of 57.6 (95% CI 37.2-89.0) versus people with the baseline non-risk genotype at both.
Talk to an eye doctor about age-related macular degeneration risk and screening rather than acting on genotype alone — regular dilated eye exams are how this is actually monitored.
rs10490924 is a single position in the genome, in or near the ARMS2 gene. Published research associates it with age-related macular degeneration. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs10490924 linked to?
On MyGeneLog this position is linked to Age-Related Macular Degeneration. The research behind each link, and its sources, are set out on that condition page.
Does having rs10490924 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs10490924 come from?
Rivera et al. 2005, Human Molecular Genetics — LOC387715/ARMS2 is a second major AMD susceptibility gene, independent of CFH. PMID 16174643. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.