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Glaucoma

RUNX1 · rs10483029

Where this position leads

Condition: Glaucoma

rs10483029 Condition: Glaucoma Glaucoma Condition rs10483029 rs10483029 RUNX1

What the study found

Who was studied 38,064 African American or Afro-Caribbean cases, 76,856 African American or Afro-Caribbean controls, 11,570 Hispanic or Latin American cases, 45,339 Hispanic or Latin American controls, 1,446 East Asian ancestry cases, 5,057 East Asian ancestry controls, 81,303 European ancestry cases, 349,418 European ancestry controls.

The effect Each copy of the G allele shifted the measure 0.0976 lower (95% confidence interval 0.076-0.119); p = 4 × 10−15.

How common The G allele had a frequency of about 96% in the people studied.

Where it sits Chromosome 21, band 21q22.12 — in an intron of RUNX1.

What each result means

C/C Published research associates this genotype with typical/baseline likelihood of Glaucoma — no copies of the reported risk allele.
C/G Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Glaucoma.
G/G Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Glaucoma compared to the general population.
Source
Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program
Verma A, Huffman JE, Rodriguez A, Conery M, Liu M, Ho YL, Kim Y, Heise DA, Guare L, Panickan VA, Garcon H, Linares F
and 59 more — show all
Costa L, Goethert I, Tipton R, Honerlaw J, Davies L, Whitbourne S, Cohen J, Posner DC, Sangar R, Murray M, Wang X, Dochtermann DR, Devineni P, Shi Y, Nandi TN, Assimes TL, Brunette CA, Carroll RJ, Clifford R, Duvall S, Gelernter J, Hung A, Iyengar SK, Joseph J, Kember R, Kranzler H, Kripke CM, Levey D, Luoh SW, Merritt VC, Overstreet C, Deak JD, Grant SFA, Polimanti R, Roussos P, Shakt G, Sun YV, Tsao N, Venkatesh S, Voloudakis G, Justice A, Begoli E, Ramoni R, Tourassi G, Pyarajan S, Tsao P, O'Donnell CJ, Muralidhar S, Moser J, Casas JP, Bick AG, Zhou W, Cai T, Voight BF, Cho K, Gaziano JM, Madduri RK, Damrauer S, Liao KP
Science (New York, N.Y.) · 2024 · PMID 39024449 · open access

Questions about rs10483029

What is rs10483029?

rs10483029 is a single position in the genome, in or near the RUNX1 gene. Published research associates it with glaucoma. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs10483029 linked to?

On MyGeneLog this position is linked to Glaucoma. The research behind each link, and its sources, are set out on that condition page.

Does having rs10483029 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs10483029 come from?

GWAS Catalog, Science (New York, N.Y.) 2024, PMID:39024449. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Glaucoma (rs10483029). MyGeneLog™. https://www.mygenelog.com/variants/rs10483029

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