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Takes medication for Glaucoma?

TXNRD2 · rs1044732

Where this position leads

Condition: Glaucoma

rs1044732 Condition: Glaucoma Glaucoma Condition rs1044732 rs1044732 TXNRD2

What the study found

Who was studied 4,849 African American or Afro-Caribbean cases, 50,656 African American or Afro-Caribbean controls, 1,360 Hispanic or Latin American cases, 27,954 Hispanic or Latin American controls, 201 East Asian ancestry cases, 3,346 East Asian ancestry controls, 13,744 European ancestry cases, 301,924 European ancestry controls.

The effect Each copy of the T allele shifted the measure 0.14 higher (95% confidence interval 0.1-0.18); p = 4 × 10−15.

How common The T allele had a frequency of about 87% in the people studied.

Where it sits Chromosome 22, band 22q11.21 — in the 3′ untranslated region of TXNRD2.

What each result means

C/C Published research associates this genotype with typical/baseline likelihood of Takes medication for Glaucoma? — no copies of the reported risk allele.
C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Takes medication for Glaucoma?.
T/T Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Takes medication for Glaucoma? compared to the general population.
Source
Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program
Verma A, Huffman JE, Rodriguez A, Conery M, Liu M, Ho YL, Kim Y, Heise DA, Guare L, Panickan VA, Garcon H, Linares F
and 59 more — show all
Costa L, Goethert I, Tipton R, Honerlaw J, Davies L, Whitbourne S, Cohen J, Posner DC, Sangar R, Murray M, Wang X, Dochtermann DR, Devineni P, Shi Y, Nandi TN, Assimes TL, Brunette CA, Carroll RJ, Clifford R, Duvall S, Gelernter J, Hung A, Iyengar SK, Joseph J, Kember R, Kranzler H, Kripke CM, Levey D, Luoh SW, Merritt VC, Overstreet C, Deak JD, Grant SFA, Polimanti R, Roussos P, Shakt G, Sun YV, Tsao N, Venkatesh S, Voloudakis G, Justice A, Begoli E, Ramoni R, Tourassi G, Pyarajan S, Tsao P, O'Donnell CJ, Muralidhar S, Moser J, Casas JP, Bick AG, Zhou W, Cai T, Voight BF, Cho K, Gaziano JM, Madduri RK, Damrauer S, Liao KP
Science (New York, N.Y.) · 2024 · PMID 39024449 · open access

Questions about rs1044732

What is rs1044732?

rs1044732 is a single position in the genome, in or near the TXNRD2 gene. Published research associates it with takes medication for glaucoma?. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs1044732 linked to?

On MyGeneLog this position is linked to Glaucoma. The research behind each link, and its sources, are set out on that condition page.

Does having rs1044732 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs1044732 come from?

GWAS Catalog, Science (New York, N.Y.) 2024, PMID:39024449. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

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Takes medication for Glaucoma? (rs1044732). MyGeneLog™. https://www.mygenelog.com/variants/rs1044732

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