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Sensitive

Type 2 diabetes

GLP1R · rs10305420

Where this position leads

Condition: Type 2 Diabetes

rs10305420 Condition: Type 2 Diabetes Type 2 Diabetes Condition rs10305420 rs10305420 GLP1R

What the study found

Who was studied 148,726 European ancestry cases, 965,732 European ancestry controls.

The effect Each copy of the C allele shifted the measure 0.0316 higher (95% confidence interval 0.022-0.041); p = 3 × 10−11.

How common The C allele had a frequency of about 62% in the people studied.

Where it sits Chromosome 6, band 6p21.2 — a missense change in GLP1R.

What each result means

C/C Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Type 2 diabetes compared to the general population.
C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Type 2 diabetes.
T/T Published research associates this genotype with typical/baseline likelihood of Type 2 diabetes — no copies of the reported risk allele.
Source
Discovery of 318 new risk loci for type 2 diabetes and related vascular outcomes among 1.4 million participants in a multi-ancestry meta-analysis
Vujkovic M, Keaton JM, Lynch JA, Miller DR, Zhou J, Tcheandjieu C, Huffman JE, Assimes TL, Lorenz K, Zhu X, Hilliard AT, Judy RL
and 35 more — show all
Huang J, Lee KM, Klarin D, Pyarajan S, Danesh J, Melander O, Rasheed A, Mallick NH, Hameed S, Qureshi IH, Afzal MN, Malik U, Jalal A, Abbas S, Sheng X, Gao L, Kaestner KH, Susztak K, Sun YV, DuVall SL, Cho K, Lee JS, Gaziano JM, Phillips LS, Meigs JB, Reaven PD, Wilson PW, Edwards TL, Rader DJ, Damrauer SM, O'Donnell CJ, Tsao PS, Chang KM, Voight BF, Saleheen D
HPAP Consortium · Regeneron Genetics Center · VA Million Veteran Program
Nature genetics · 2020 · PMID 32541925 · open access

Questions about rs10305420

What is rs10305420?

rs10305420 is a single position in the genome, in or near the GLP1R gene. Published research associates it with type 2 diabetes. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs10305420 linked to?

On MyGeneLog this position is linked to Type 2 Diabetes. The research behind each link, and its sources, are set out on that condition page.

Does having rs10305420 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs10305420 come from?

GWAS Catalog, Nature genetics 2020, PMID:32541925. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Type 2 diabetes (rs10305420). MyGeneLog™. https://www.mygenelog.com/variants/rs10305420

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