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Who was studied 47,745 European ancestry individuals.
The effect
Each copy of the G allele shifted the measure 0.311 lower (95% confidence interval 0.27-0.35); p = 9 × 10−86.
How common The G allele had a frequency of about 1% in the people studied.
Where it sits Chromosome 7, band 7q22.1 — in an intron of CYP3A5.
What each result means
A/ANo copy of the version the research linked to PILRB protein levels. This is the starting point the study compared everyone against.
A/GOne copy of the version the research linked to PILRB protein levels. That is a smaller link than two copies.
G/GTwo copies of the version the research linked to PILRB protein levels. That is the strongest link of the three results. A link in a study is not a diagnosis.
Nature genetics · 2025 · PMID 39789286 · open access
Questions about rs10249369
What is rs10249369?
rs10249369 is a single position in the genome, in or near the CYP3A5 gene. Published research associates it with pilrb protein levels. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs10249369 linked to?
On MyGeneLog this position is linked to Celiac Disease. The research behind each link, and its sources, are set out on that condition page.
Does rs10249369 affect how medicines work?
CYP3A5 carries pharmacogenomic findings for Tacrolimus. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.
Does having rs10249369 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs10249369 come from?
GWAS Catalog, Nature genetics 2025, PMID:39789286. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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Quoting this page
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
PILRB protein levels (rs10249369). MyGeneLog™. https://www.mygenelog.com/variants/rs10249369