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Who was studied 182,798 British ancestry individuals.
The effect
Each copy of the T allele shifted the measure 0.0179 lower; p = 2 × 10−8.
How common The T allele had a frequency of about 48% in the people studied.
Where it sits Chromosome 7, band 7q22.3 — in an intron of KMT2E.
What each result means
C/CNo copy of the version the research linked to Fluid intelligence. This is the starting point the study compared everyone against.
C/TOne copy of the version the research linked to Fluid intelligence. That is a smaller link than two copies.
T/TTwo copies of the version the research linked to Fluid intelligence. That is the strongest link of the three results. A link in a study is not a diagnosis.
Communications biology · 2026 · PMID 42092107 · open access
Questions about rs10228174
What is rs10228174?
rs10228174 is a single position in the genome, in or near the KMT2E gene. Published research associates it with fluid intelligence. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs10228174 linked to?
On MyGeneLog this position is linked to Intelligence. The research behind each link, and its sources, are set out on that condition page.
Does having rs10228174 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs10228174 come from?
GWAS Catalog, Communications biology 2026, PMID:42092107. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
0 00Reads by AI crawlersClaude0ChatGPT0Google · Gemini0Perplexity0Meta AI0Microsoft · Copilot0Amazon0Apple0China (ByteDance, Huawei, Baidu…)0Others0Total0Counted by the name each crawler declares; requests found to be impersonating one are left out. Google · Gemini includes Googlebot, the search crawler whose index Google also uses for its AI features. Other search engines and bots are under Others.
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