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Optic disc area

UGT8 · rs10021731

Where this position leads

Condition: Glaucoma

rs10021731 Condition: Glaucoma Glaucoma Condition rs10021731 rs10021731 UGT8

What the study found

Who was studied 20,373 European ancestry individuals, 2,131 Erasmus Rucphen (founder/genetic isolate) individuals; replicated in 7,302 Asian ancestry individuals.

The effect Each copy of the C allele shifted the measure 0.02 lower (95% confidence interval 0.012-0.028); p = 4 × 10−7.

Where it sits Chromosome 4, band 4q26 — between genes, 2 kb from LOC105377380.

What each result means

C/C Two copies of the version the research linked to Optic disc area. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/T One copy of the version the research linked to Optic disc area. That is a smaller link than two copies.
T/T No copy of the version the research linked to Optic disc area. This is the starting point the study compared everyone against.
Source
New insights into the genetics of primary open-angle glaucoma based on meta-analyses of intraocular pressure and optic disc characteristics
Springelkamp H, Iglesias AI, Mishra A, Höhn R, Wojciechowski R, Khawaja AP, Nag A, Wang YX, Wang JJ, Cuellar-Partida G, Gibson J, Bailey JN
and 71 more — show all
Vithana EN, Gharahkhani P, Boutin T, Ramdas WD, Zeller T, Luben RN, Yonova-Doing E, Viswanathan AC, Yazar S, Cree AJ, Haines JL, Koh JY, Souzeau E, Wilson JF, Amin N, Müller C, Venturini C, Kearns LS, Kang JH, Tham YC, Zhou T, van Leeuwen EM, Nickels S, Sanfilippo P, Liao J, van der Linde H, Zhao W, van Koolwijk LM, Zheng L, Rivadeneira F, Baskaran M, van der Lee SJ, Perera S, de Jong PT, Oostra BA, Uitterlinden AG, Fan Q, Hofman A, Tai ES, Vingerling JR, Sim X, Wolfs RC, Teo YY, Lemij HG, Khor CC, Willemsen R, Lackner KJ, Aung T, Jansonius NM, Montgomery G, Wild PS, Young TL, Burdon KP, Hysi PG, Pasquale LR, Wong TY, Klaver CC, Hewitt AW, Jonas JB, Mitchell P, Lotery AJ, Foster PJ, Vitart V, Pfeiffer N, Craig JE, Mackey DA, Hammond CJ, Wiggs JL, Cheng CY, van Duijn CM, MacGregor S
NEIGHBORHOOD Consortium
Human molecular genetics · 2017 · PMID 28073927

Questions about rs10021731

What is rs10021731?

rs10021731 is a single position in the genome, in or near the UGT8 gene. Published research associates it with optic disc area. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs10021731 linked to?

On MyGeneLog this position is linked to Glaucoma. The research behind each link, and its sources, are set out on that condition page.

Does having rs10021731 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs10021731 come from?

GWAS Catalog, Hum Mol Genet 2017, PMID:28073927. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

Quoting this page

Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.

Optic disc area (rs10021731). MyGeneLog™. https://www.mygenelog.com/variants/rs10021731

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