Ulcer of Esophagus, as genome-wide studies have reported it: 11 positions from 1 study, the largest recording 3,164 cases and 625,341 controls (African American or Afro-Caribbean ancestry, European ancestry, Hispanic or Latin American ancestry). Assembled by code from the GWAS Catalog's records and kept current as positions arrive; every figure is the studies' own.
1 study in the GWAS Catalog report 11 positions for Ulcer of Esophagus, which the catalogue files as "Ulcer of esophagus (PheCode 530.12)". MyGeneLog follows the condition as positions arrive: code builds this page from the records, adds each new position when it is reported, and writes no sentence of its own beyond them.
Verma A et al. 2024, in Science — Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program. The catalogue records its sample as 3,164 cases and 625,341 controls (African American or Afro-Caribbean ancestry, European ancestry, Hispanic or Latin American ancestry). It contributes 11 positions: rs540106964 (near CDH2-AS1), rs183121790 (near TRPC6P5), rs190188858 (LINC00540), rs573908805 (LINC02315), rs563013416 (near ELF2P2), rs149697790 (near SASH1), rs535597961 (near GAPDHP56), rs541166768 (LINC01060), and 3 more. PMID:39024449.
The 11 positions lie in or near 11 genes: CDH2-AS1, TRPC6P5, LINC00540, LINC02315, ELF2P2, SASH1, GAPDHP56, LINC01060, SPATS2L, TPM1-AS, ALPK3. A gene named here is the catalogue's mapped location for a position, not a mechanism; the studies are cited above so that a reader can go to them.
The strongest association in the records is rs540106964 near CDH2-AS1, reported by Verma A et al. 2024 at P = 4 × 10-14.
Read this page as a list of findings about Ulcer of Esophagus, not as an account of it. Each finding is a position that a genome-wide study linked to the condition across a population; the page adds no description, no prevalence and no advice, because the records hold none. The variant pages linked above give each study's record for its position, and ClinVar's where one exists.
Ulcer of Esophagus is diagnosed by a clinician — not from a genotype. None of the 11 variants on this page is used by any guideline to predict, screen for or diagnose it.
Everything here comes from population-level association records, put together by code. Those records compare groups of people; they do not examine anyone, and they give no guidance on care. For symptoms, testing or treatment, ask a clinician.
What a 23andMe/AncestryDNA export or raw VCF can and can't tell you about Ulcer of Esophagus comes down to these specific, well-studied positions — not a diagnosis.
Databases, guidelines and references
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Ulcer of Esophagus. MyGeneLog™. https://www.mygenelog.com/conditions/ulcer-of-esophagus
Ulcer of Esophagus is the condition the GWAS Catalog files under "Ulcer of esophagus (PheCode 530.12)". This page does not define it in its own words; it lists what genome-wide studies have reported: 11 positions from 1 study, with each study's sample and citation.
Genes play a part: 11 positions have been linked to it, the largest study recording 3,164 cases and 625,341 controls (African American or Afro-Caribbean ancestry, European ancestry, Hispanic or Latin American ancestry). But each is a common variant of small effect, and a link found across a population does not cause the condition in any one person.
The positions lie in or near 11 genes: CDH2-AS1, TRPC6P5, LINC00540, LINC02315, ELF2P2, SASH1, GAPDHP56, LINC01060, SPATS2L, TPM1-AS, ALPK3. A mapped gene is the catalogue's location for a position, not a mechanism.
No. Each variant shifts the odds only slightly, and only on average across many people. No guideline predicts Ulcer of Esophagus from a genotype; a clinician diagnoses it.
Free to reuse. This page's text is original writing from freely-available research, licensed CC BY 4.0 — reuse it, including commercially, with attribution to MyGeneLog™. It's general research-derived information, not medical advice or a diagnosis — see Terms of Use.