Palmoplantar Pustulosis, as genome-wide studies have reported it: 2 positions from 1 study, the largest recording 1,456 cases and 402,050 controls (European ancestry). Built from the GWAS Catalog's records and rebuilt when a new position is reported; the figures are the studies'.
1 study in the GWAS Catalog report 2 positions for Palmoplantar Pustulosis, which the catalogue files as "Palmoplantar pustulosis". MyGeneLog follows the condition as positions arrive: code builds this page from the records, adds each new position when it is reported, and writes no sentence of its own beyond them.
Hernandez-Cordero A et al. 2024, in The Journal of Allergy and Clinical Immunology — A genome-wide meta-analysis of palmoplantar pustulosis implicates TH2 responses and cigarette smoking in disease pathogenesis. Studied in 1,456 cases and 402,050 controls (European ancestry). From it, 2 positions on this page: rs887467 (POU5F1), rs61802325 (near FCGR3B). PMID:38815935.
The catalogue maps the 2 positions to 2 genes: POU5F1, FCGR3B. That mapping says where a position sits, in a gene or beside one — not what it does. For what each study measured, follow its citation above.
Of all these, rs887467 in POU5F1 carries the strongest signal: P = 3 × 10-11, with an odds ratio of 0.75, in Hernandez-Cordero A et al. 2024.
Read this page as a list of findings about Palmoplantar Pustulosis, not as an account of it. Each finding is a position that a genome-wide study linked to the condition across a population; the page adds no description, no prevalence and no advice, because the records hold none. The variant pages linked above give each study's record for its position, and ClinVar's where one exists.
Nothing on this page diagnoses Palmoplantar Pustulosis. The 2 variants here are research findings; no guideline uses them to predict, screen for or diagnose the condition — that is a clinician's work.
Everything here comes from population-level association records, put together by code. Those records compare groups of people; they do not examine anyone, and they give no guidance on care. For symptoms, testing or treatment, ask a clinician.
What a 23andMe/AncestryDNA export or raw VCF can and can't tell you about Palmoplantar Pustulosis comes down to these specific, well-studied positions — not a diagnosis.
Databases, guidelines and references
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Palmoplantar Pustulosis. MyGeneLog™. https://www.mygenelog.com/conditions/palmoplantar-pustulosis
In the GWAS Catalog, Palmoplantar Pustulosis is filed as "Palmoplantar pustulosis". Rather than define it, this page lists the genome-wide findings: 2 positions from 1 study, each with its study's sample and citation.
Genes play a part: 2 positions have been linked to it, the largest study recording 1,456 cases and 402,050 controls (European ancestry). But each is a common variant of small effect, and a link found across a population does not cause the condition in any one person.
The positions lie in or near 2 genes: POU5F1, FCGR3B. A mapped gene is the catalogue's location for a position, not a mechanism.
No. They are population-level findings of small effect. Palmoplantar Pustulosis is diagnosed by a clinician, and no guideline uses a genotype to predict it.
Free to reuse. This page's text is original writing from freely-available research, licensed CC BY 4.0 — reuse it, including commercially, with attribution to MyGeneLog™. It's general research-derived information, not medical advice or a diagnosis — see Terms of Use.