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Who was studied 1,456 European ancestry cases, 402,050 European ancestry controls.
The effect
Each copy of the C allele carried 0.75 times the odds of Palmoplantar pustulosis (95% confidence interval 0.72-0.79); p = 3 × 10−11.
How common The C allele had a frequency of about 48% in the people studied.
Where it sits Chromosome 6, band 6p21.33 — in a non-coding transcript of POU5F1.
What each result means
C/CTwo copies of the version the research linked to Palmoplantar pustulosis. That is the strongest link of the three results. A link in a study is not a diagnosis.
C/GOne copy of the version the research linked to Palmoplantar pustulosis. That is a smaller link than two copies.
G/GNo copy of the version the research linked to Palmoplantar pustulosis. This is the starting point the study compared everyone against.
The Journal of allergy and clinical immunology · 2024 · PMID 38815935
Questions about rs887467
What is rs887467?
rs887467 is a single position in the genome, in or near the POU5F1 gene. Published research associates it with palmoplantar pustulosis. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
What conditions is rs887467 linked to?
On MyGeneLog this position is linked to Palmoplantar Pustulosis. The research behind each link, and its sources, are set out on that condition page.
Does having rs887467 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs887467 come from?
GWAS Catalog, The Journal of allergy and clinical immunology 2024, PMID:38815935. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.
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