Non-alcoholic Chronic Pancreatitis, as genome-wide studies have reported it: 2 positions from 1 study, the largest recording 584 cases and 6,040 controls (European ancestry). Assembled by code from the GWAS Catalog's records and kept current as positions arrive; every figure is the studies' own.
1 study in the GWAS Catalog report 2 positions for Non-alcoholic Chronic Pancreatitis, which the catalogue files as "Non-alcoholic chronic pancreatitis". MyGeneLog follows the condition as positions arrive: code builds this page from the records, adds each new position when it is reported, and writes no sentence of its own beyond them.
Schmidt AW et al. 2022, in Pancreatology — Colocalization analysis of pancreas eQTLs with risk loci from alcoholic and novel non-alcoholic chronic pancreatitis GWAS suggests potential disease causing mechanisms. Sample in the catalogue's record: 584 cases and 6,040 controls (European ancestry). From it, 2 positions on this page: rs17107296 (near SPINK1), rs112861203 (near SPINK5). PMID:35331647.
The 2 positions lie in or near 2 genes: SPINK1, SPINK5. A gene named here is the catalogue's mapped location for a position, not a mechanism; the studies are cited above so that a reader can go to them.
Schmidt AW et al. 2022 reported the smallest P value on this page — P = 7 × 10-47, with an odds ratio of 11.2 — at rs17107296 near SPINK1.
Association records say which positions differ, on average, between people with Non-alcoholic Chronic Pancreatitis and people without. They do not describe the condition, say how common it is, or tell anyone what to do, so this page does not either. For a single position, open its variant page: it gives that study's record in fixed sentences, with ClinVar's where there is one.
A genotype does not diagnose Non-alcoholic Chronic Pancreatitis; a clinician does. No guideline uses the 2 variants on this page to predict it, screen for it or confirm it.
Everything here comes from population-level association records, put together by code. Those records compare groups of people; they do not examine anyone, and they give no guidance on care. For symptoms, testing or treatment, ask a clinician.
What a 23andMe/AncestryDNA export or raw VCF can and can't tell you about Non-alcoholic Chronic Pancreatitis comes down to these specific, well-studied positions — not a diagnosis.
Databases, guidelines and references
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Non-alcoholic Chronic Pancreatitis. MyGeneLog™. https://www.mygenelog.com/conditions/non-alcoholic-chronic-pancreatitis
In the GWAS Catalog, Non-alcoholic Chronic Pancreatitis is filed as "Non-alcoholic chronic pancreatitis". Rather than define it, this page lists the genome-wide findings: 2 positions from 1 study, each with its study's sample and citation.
Genome-wide studies have reported 2 associated positions; the largest study behind this page recorded 584 cases and 6,040 controls (European ancestry). Each common variant has a small effect, and an association in a population is not a cause in any one person.
The positions lie in or near 2 genes: SPINK1, SPINK5. A mapped gene is the catalogue's location for a position, not a mechanism.
No. They are population-level findings of small effect. Non-alcoholic Chronic Pancreatitis is diagnosed by a clinician, and no guideline uses a genotype to predict it.
Free to reuse. This page's text is original writing from freely-available research, licensed CC BY 4.0 — reuse it, including commercially, with attribution to MyGeneLog™. It's general research-derived information, not medical advice or a diagnosis — see Terms of Use.