Nephrotic Syndrome without Mention of Glomerulonephritis, as genome-wide studies have reported it: 12 positions from 1 study, the largest recording 1,865 cases and 629,378 controls (African American or Afro-Caribbean ancestry, European ancestry, Hispanic or Latin American ancestry). Assembled by code from the GWAS Catalog's records and kept current as positions arrive; every figure is the studies' own.
Nephrotic Syndrome without Mention of Glomerulonephritis — filed in the GWAS Catalog as "Nephrotic syndrome without mention of glomerulonephritis (PheCode 580.2)" — is a condition this catalogue follows as its positions arrive. This page is assembled by MyGeneLog's own code from the catalogue's records and the studies' own listings: 12 positions from 1 study, and no sentence written by hand. It is rebuilt as new positions are reported, so what it says is what the records say today.
Verma A et al. 2024, in Science — Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program. Studied in 1,865 cases and 629,378 controls (African American or Afro-Caribbean ancestry, European ancestry, Hispanic or Latin American ancestry). From it, 12 positions on this page: rs188468626 (ARID3B), rs190789398 (DOCK8), rs534357542 (near LINC02740), rs538515780 (LIMA1), rs143538480 (SEMA3E), rs118076421 (near ZNF469), rs190692818 (SFMBT2), rs529814603 (SLC6A18), and 4 more. PMID:39024449.
The 12 positions lie in or near 12 genes: ARID3B, DOCK8, LINC02740, LIMA1, SEMA3E, ZNF469, SFMBT2, SLC6A18, PDIA4, LINC02443, UNC93B5, SCYGR5. A gene named here is the catalogue's mapped location for a position, not a mechanism; the studies are cited above so that a reader can go to them.
Of all these, rs188468626 in ARID3B carries the strongest signal: P = 3 × 10-14, in Verma A et al. 2024.
Association records say which positions differ, on average, between people with Nephrotic Syndrome without Mention of Glomerulonephritis and people without. They do not describe the condition, say how common it is, or tell anyone what to do, so this page does not either. For a single position, open its variant page: it gives that study's record in fixed sentences, with ClinVar's where there is one.
Nothing on this page diagnoses Nephrotic Syndrome without Mention of Glomerulonephritis. The 12 variants here are research findings; no guideline uses them to predict, screen for or diagnose the condition — that is a clinician's work.
Everything here comes from population-level association records, put together by code. Those records compare groups of people; they do not examine anyone, and they give no guidance on care. For symptoms, testing or treatment, ask a clinician.
What a 23andMe/AncestryDNA export or raw VCF can and can't tell you about Nephrotic Syndrome without Mention of Glomerulonephritis comes down to these specific, well-studied positions — not a diagnosis.
near LINC02443 · rs184305217
See detailed info →ARID3B · rs188468626
See detailed info →DOCK8 · rs190789398
See detailed info →near LINC02740 · rs534357542
See detailed info →LIMA1 · rs538515780
See detailed info →SEMA3E · rs143538480
See detailed info →near ZNF469 · rs118076421
See detailed info →SFMBT2 · rs190692818
See detailed info →SLC6A18 · rs529814603
See detailed info →near PDIA4 · rs572850354
See detailed info →near UNC93B5 · rs555013895
See detailed info →near SCYGR5 · rs191924967
See detailed info →Databases, guidelines and references
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Nephrotic Syndrome without Mention of Glomerulonephritis. MyGeneLog™. https://www.mygenelog.com/conditions/nephrotic-syndrome-without-mention-of-glomerulonephritis
Nephrotic Syndrome without Mention of Glomerulonephritis is the condition the GWAS Catalog files under "Nephrotic syndrome without mention of glomerulonephritis (PheCode 580.2)". This page does not define it in its own words; it lists what genome-wide studies have reported: 12 positions from 1 study, with each study's sample and citation.
Genome-wide studies have reported 12 associated positions; the largest study behind this page recorded 1,865 cases and 629,378 controls (African American or Afro-Caribbean ancestry, European ancestry, Hispanic or Latin American ancestry). Each common variant has a small effect, and an association in a population is not a cause in any one person.
The catalogue maps the positions to 12 genes: ARID3B, DOCK8, LINC02740, LIMA1, SEMA3E, ZNF469, SFMBT2, SLC6A18, PDIA4, LINC02443, UNC93B5, SCYGR5. These are where the positions sit, not proof of how they act.
No. Each variant shifts the odds only slightly, and only on average across many people. No guideline predicts Nephrotic Syndrome without Mention of Glomerulonephritis from a genotype; a clinician diagnoses it.
Free to reuse. This page's text is original writing from freely-available research, licensed CC BY 4.0 — reuse it, including commercially, with attribution to MyGeneLog™. It's general research-derived information, not medical advice or a diagnosis — see Terms of Use.