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Lymphocytic Leukemia, as genome-wide studies have reported it: 5 positions from 1 study, the largest recording 852 cases and 410,350 controls (European ancestry). Assembled by code from the GWAS Catalog's records and kept current as positions arrive; every figure is the studies' own.
1 study in the GWAS Catalog report 5 positions for Lymphocytic Leukemia, which the catalogue files as "Lymphocytic leukemia". MyGeneLog follows the condition as positions arrive: code builds this page from the records, adds each new position when it is reported, and writes no sentence of its own beyond them.
Rashkin SR et al. 2020, in Nature Communications — Pan-cancer study detects genetic risk variants and shared genetic basis in two large cohorts. Studied in 852 cases and 410,350 controls (European ancestry). From it, 5 positions on this page: rs187021028 (LINC01785), rs2316515 (IRF4), rs114490818 (CFAP100-DT), rs61965473 (near LINC00557), rs6710287 (SP140L). PMID:32887889.
The catalogue maps the 5 positions to 5 genes: LINC01785, IRF4, CFAP100-DT, LINC00557, SP140L. That mapping says where a position sits, in a gene or beside one — not what it does. For what each study measured, follow its citation above.
Rashkin SR et al. 2020 reported the smallest P value on this page — P = 9 × 10-9, with an odds ratio of 0.39 — at rs187021028 in LINC01785.
Association records say which positions differ, on average, between people with Lymphocytic Leukemia and people without. They do not describe the condition, say how common it is, or tell anyone what to do, so this page does not either. For a single position, open its variant page: it gives that study's record in fixed sentences, with ClinVar's where there is one.
A genotype does not diagnose Lymphocytic Leukemia; a clinician does. No guideline uses the 5 variants on this page to predict it, screen for it or confirm it.
This page was assembled by code from association records. It holds no clinical guidance, because its sources hold none: a genome-wide study reports which positions differ between people with a condition and people without, at the population level, and that is all this page repeats. A question about a symptom, a test or a treatment belongs with a clinician.
Databases, guidelines and references
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Lymphocytic Leukemia. MyGeneLog™. https://www.mygenelog.com/conditions/lymphocytic-leukemia
Lymphocytic Leukemia is the condition the GWAS Catalog files under "Lymphocytic leukemia". This page does not define it in its own words; it lists what genome-wide studies have reported: 5 positions from 1 study, with each study's sample and citation.
Genome-wide studies have reported 5 associated positions; the largest study behind this page recorded 852 cases and 410,350 controls (European ancestry). Each common variant has a small effect, and an association in a population is not a cause in any one person.
The positions lie in or near 5 genes: LINC01785, IRF4, CFAP100-DT, LINC00557, SP140L. A mapped gene is the catalogue's location for a position, not a mechanism.
No. Each variant shifts the odds only slightly, and only on average across many people. No guideline predicts Lymphocytic Leukemia from a genotype; a clinician diagnoses it.
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