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Ischemic Heart Disease, as genome-wide studies have reported it: 8 positions from 2 studies, the largest recording 181,290 cases and 408,425 controls (African American or Afro-Caribbean ancestry, Hispanic or Latin American ancestry, East Asian ancestry, European ancestry). Every figure comes from the studies themselves, gathered by code from the GWAS Catalog and updated as the records grow.
This is the record of what genome-wide association studies have found for Ischemic Heart Disease (the GWAS Catalog's "Ischemic heart disease (PheCode 411)"): 8 positions reported by 2 studies. The page is put together by code from the catalogue's records and the studies' own listings, and it is rebuilt whenever the records change, so it always reflects them as they stand.
Zhou W et al. 2018, in Nature Genetics — Efficiently controlling for case-control imbalance and sample relatedness in large-scale genetic association studies. The catalogue records its sample as 31,355 cases and 377,103 controls. The 7 positions on this page from it: rs12194592 (TARID), rs638634 (COL4A1), rs11238907 (near LINC03089), rs550780826 (near LINC01929), rs150282530 (TRPM3), rs378825 (SWAP70), rs430918 (near RAB23). PMID:30104761.
Verma A et al. 2024, in Science — Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program. Studied in 181,290 cases and 408,425 controls (African American or Afro-Caribbean ancestry, Hispanic or Latin American ancestry, East Asian ancestry, European ancestry). From it, one position on this page: rs10509759 (CNNM2). PMID:39024449.
The 8 positions lie in or near 8 genes: TARID, COL4A1, LINC03089, LINC01929, TRPM3, SWAP70, RAB23, CNNM2. A gene named here is the catalogue's mapped location for a position, not a mechanism; the studies are cited above so that a reader can go to them.
Verma A et al. 2024 reported the smallest P value on this page — P = 8 × 10-14 — at rs10509759 in CNNM2.
Read this page as a list of findings about Ischemic Heart Disease, not as an account of it. Each finding is a position that a genome-wide study linked to the condition across a population; the page adds no description, no prevalence and no advice, because the records hold none. The variant pages linked above give each study's record for its position, and ClinVar's where one exists.
Ischemic Heart Disease is diagnosed by a clinician — not from a genotype. None of the 8 variants on this page is used by any guideline to predict, screen for or diagnose it.
This page was assembled by code from association records. It holds no clinical guidance, because its sources hold none: a genome-wide study reports which positions differ between people with a condition and people without, at the population level, and that is all this page repeats. A question about a symptom, a test or a treatment belongs with a clinician.
Databases, guidelines and references
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Ischemic Heart Disease. MyGeneLog™. https://www.mygenelog.com/conditions/ischemic-heart-disease
Ischemic Heart Disease is the condition the GWAS Catalog files under "Ischemic heart disease (PheCode 411)". This page does not define it in its own words; it lists what genome-wide studies have reported: 8 positions from 2 studies, with each study's sample and citation.
Genome-wide studies have reported 8 associated positions; the largest study behind this page recorded 181,290 cases and 408,425 controls (African American or Afro-Caribbean ancestry, Hispanic or Latin American ancestry, East Asian ancestry, European ancestry). Each common variant has a small effect, and an association in a population is not a cause in any one person.
The positions lie in or near 8 genes: TARID, COL4A1, LINC03089, LINC01929, TRPM3, SWAP70, RAB23, CNNM2. A mapped gene is the catalogue's location for a position, not a mechanism.
No. Each variant shifts the odds only slightly, and only on average across many people. No guideline predicts Ischemic Heart Disease from a genotype; a clinician diagnoses it.
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