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Immunoglobulin a Vasculitis, as genome-wide studies have reported it: 29 positions from 1 study, the largest recording 46 cases and 18,757 controls. Assembled by code from the GWAS Catalog's records and kept current as positions arrive; every figure is the studies' own.
1 study in the GWAS Catalog report 29 positions for Immunoglobulin a Vasculitis, which the catalogue files as "Immunoglobulin A vasculitis". MyGeneLog follows the condition as positions arrive: code builds this page from the records, adds each new position when it is reported, and writes no sentence of its own beyond them.
Koskela M et al. 2021, in Pediatric Nephrology — HLA-DQ and HLA-DRB1 alleles associated with Henoch-Schönlein purpura nephritis in Finnish pediatric population: a genome-wide association study. Studied in 46 cases and 18,757 controls. From it, 29 positions on this page: rs7754768 (near HLA-DRA), rs9268832 (HLA-DRB9), rs9275582 (near MTCO3P1), rs3763327 (near HLA-DRA), rs7195 (HLA-DRA), rs3998158 (near MTCO3P1), rs112396255 (near HLA-DQA1), rs17533090 (near HLA-DQA1), and 21 more. PMID:33591409.
The 29 positions sit in or beside 5 genes: HLA-DRA, HLA-DRB9, MTCO3P1, HLA-DQA1, TSBP1-AS1. These are locations, as the catalogue records them; whether any of these genes is how a position acts is a question the records leave open.
Koskela M et al. 2021 reported the smallest P value on this page — P = 7 × 10-10, with an odds ratio of 0.14 — at rs7754768 near HLA-DRA.
Association records say which positions differ, on average, between people with Immunoglobulin a Vasculitis and people without. They do not describe the condition, say how common it is, or tell anyone what to do, so this page does not either. For a single position, open its variant page: it gives that study's record in fixed sentences, with ClinVar's where there is one.
Nothing on this page diagnoses Immunoglobulin a Vasculitis. The 29 variants here are research findings; no guideline uses them to predict, screen for or diagnose the condition — that is a clinician's work.
Its sources are association records, and association records carry no clinical guidance, so neither does this page. What a genome-wide study reports is a difference between groups of people, not a finding about any one person. Symptoms, tests and treatment are questions for a clinician.
Databases, guidelines and references
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Immunoglobulin a Vasculitis. MyGeneLog™. https://www.mygenelog.com/conditions/immunoglobulin-a-vasculitis
Immunoglobulin a Vasculitis is the condition the GWAS Catalog files under "Immunoglobulin A vasculitis". This page does not define it in its own words; it lists what genome-wide studies have reported: 29 positions from 1 study, with each study's sample and citation.
Genes play a part: 29 positions have been linked to it, the largest study recording 46 cases and 18,757 controls. But each is a common variant of small effect, and a link found across a population does not cause the condition in any one person.
The positions lie in or near 5 genes: HLA-DRA, HLA-DRB9, MTCO3P1, HLA-DQA1, TSBP1-AS1. A mapped gene is the catalogue's location for a position, not a mechanism.
No. Each variant shifts the odds only slightly, and only on average across many people. No guideline predicts Immunoglobulin a Vasculitis from a genotype; a clinician diagnoses it.
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