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Hippocampal atrophy

GCFC2 · rs2298948

Stands on its own. Nothing else here links to this position yet — but the page above is the point: what the research found, what each genotype means, and where it came from, in language you can read. Links to conditions, drugs and the senses appear automatically if we write them.

What each result means

C/C Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Hippocampal atrophy compared to the general population.

C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Hippocampal atrophy.

T/T Published research associates this genotype with typical/baseline likelihood of Hippocampal atrophy — no copies of the reported risk allele.

Source

Multiple loci influencing hippocampal degeneration identified by genome scan

Melville SA, Buros J, Parrado AR, Vardarajan B, Logue MW, Shen L, Risacher SL, Kim S, Jun G, DeCarli C, Lunetta KL, Baldwin CT

and 2 more — show all

Saykin AJ, Farrer LA

Alzheimer's Disease Neuroimaging Initiative

Annals of neurology · 2012 · PMID 22745009

Questions about rs2298948

What is rs2298948?

rs2298948 is a single position in the genome, in or near the GCFC2 gene. Published research associates it with hippocampal atrophy. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does having rs2298948 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs2298948 come from?

GWAS Catalog, Ann Neurol 2012, PMID:22745009. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

← See all variants