Glomerulonephritis, as genome-wide studies have reported it: 5 positions from 1 study, the largest recording 2,204 cases and 629,134 controls (African American or Afro-Caribbean ancestry, European ancestry, Hispanic or Latin American ancestry). Assembled by code from the GWAS Catalog's records and kept current as positions arrive; every figure is the studies' own.
This is the record of what genome-wide association studies have found for Glomerulonephritis (the GWAS Catalog's "Glomerulonephritis (PheCode 580.1)"): 5 positions reported by 1 study. The page is put together by code from the catalogue's records and the studies' own listings, and it is rebuilt whenever the records change, so it always reflects them as they stand.
Verma A et al. 2024, in Science — Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program. Sample in the catalogue's record: 2,204 cases and 629,134 controls (African American or Afro-Caribbean ancestry, European ancestry, Hispanic or Latin American ancestry). From it, 5 positions on this page: rs568764245 (near SLC25A28), rs183343848 (LINC03122), rs191750751 (COL6A6), rs148340088 (near PREP), rs549120028 (near RPS4XP15). PMID:39024449.
The 5 positions sit in or beside 5 genes: SLC25A28, LINC03122, COL6A6, PREP, RPS4XP15. These are locations, as the catalogue records them; whether any of these genes is how a position acts is a question the records leave open.
The strongest association in the records is rs568764245 near SLC25A28, reported by Verma A et al. 2024 at P = 3 × 10-13.
It is a record of what genome-wide studies have reported about Glomerulonephritis, kept current by code. It is not a description of the condition, an estimate of how common it is, or guidance of any kind — a page that took those from association records would be inventing them. Each variant page linked here carries that study's own record for the position in fixed sentences, and ClinVar's record where one exists.
A genotype does not diagnose Glomerulonephritis; a clinician does. No guideline uses the 5 variants on this page to predict it, screen for it or confirm it.
This page was assembled by code from association records. It holds no clinical guidance, because its sources hold none: a genome-wide study reports which positions differ between people with a condition and people without, at the population level, and that is all this page repeats. A question about a symptom, a test or a treatment belongs with a clinician.
What a 23andMe/AncestryDNA export or raw VCF can and can't tell you about Glomerulonephritis comes down to these specific, well-studied positions — not a diagnosis.
Databases, guidelines and references
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Glomerulonephritis. MyGeneLog™. https://www.mygenelog.com/conditions/glomerulonephritis
In the GWAS Catalog, Glomerulonephritis is filed as "Glomerulonephritis (PheCode 580.1)". Rather than define it, this page lists the genome-wide findings: 5 positions from 1 study, each with its study's sample and citation.
Genome-wide studies have reported 5 associated positions; the largest study behind this page recorded 2,204 cases and 629,134 controls (African American or Afro-Caribbean ancestry, European ancestry, Hispanic or Latin American ancestry). Each common variant has a small effect, and an association in a population is not a cause in any one person.
The catalogue maps the positions to 5 genes: SLC25A28, LINC03122, COL6A6, PREP, RPS4XP15. These are where the positions sit, not proof of how they act.
No. They are population-level findings of small effect. Glomerulonephritis is diagnosed by a clinician, and no guideline uses a genotype to predict it.
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