Fibromyalgia, as genome-wide studies have reported it: 6 positions from 2 studies, the largest recording 2,563,755 individuals (European ancestry, African ancestry, South Asian ancestry, Hispanic or Latin American ancestry). Assembled by code from the GWAS Catalog's records and kept current as positions arrive; every figure is the studies' own.
Genome-wide studies have so far placed 6 positions on Fibromyalgia, from 2 studies; the GWAS Catalog files the condition as "Fibromyalgia". MyGeneLog's code assembles this page from those records and rebuilds it when a new position is reported — nothing here was written by hand, and nothing here goes beyond what the records say.
Bright U et al. 2026, in Nature Communications — The genetics of fibromyalgia and its relationships to psychiatric and medical traits. Sample in the catalogue's record: 85,139 cases and 1,642,433 controls (European ancestry, African ancestry). From it, 3 positions on this page: rs72831629 (FBLN7), rs75970938 (CNNM2), rs186798404 (near SPATS1). PMID:42521668.
Kerrebijn I et al. 2026, in Nature Medicine — The genetic architecture of fibromyalgia across 2.5 million individuals. The catalogue records its sample as 2,563,755 individuals (European ancestry, African ancestry, South Asian ancestry, Hispanic or Latin American ancestry). From it, 3 positions on this page: rs2734833 (DRD2), rs62194170 (near TANK-AS1), rs34683740 (near LINC02607). PMID:42521817.
The 6 positions lie in or near 6 genes: FBLN7, CNNM2, SPATS1, DRD2, TANK-AS1, LINC02607. A gene named here is the catalogue's mapped location for a position, not a mechanism; the studies are cited above so that a reader can go to them.
The strongest association in the records is rs2734833 in DRD2, reported by Kerrebijn I et al. 2026 at P = 2 × 10-9, with an odds ratio of 0.96.
It is a record of what genome-wide studies have reported about Fibromyalgia, kept current by code. It is not a description of the condition, an estimate of how common it is, or guidance of any kind — a page that took those from association records would be inventing them. Each variant page linked here carries that study's own record for the position in fixed sentences, and ClinVar's record where one exists.
2026-07-28 · Bright U et al. The genetics of fibromyalgia and its relationships to psychiatric and medical traits. Nature Communications 2026, PMID:42521668
Fibromyalgia shares much of its genetics with depression and PTSD
Fibromyalgia, a chronic pain syndrome, has long been hard to explain. A genome-wide study combining 85,139 cases and 1,642,433 controls across European, African and Latin American ancestry found 10 loci in European-ancestry participants, 12 across ancestries and 45 in a multi-trait analysis with pain, and strong genetic correlations with chronic pain, post-traumatic stress disorder and depression, alongside a moderate negative one with physical activity. Its analyses point to neuronal mechanisms. 16 of its positions already have pages here, four of them on the fibromyalgia page. PMID:42521668.
Nothing on this page diagnoses Fibromyalgia. The 6 variants here are research findings; no guideline uses them to predict, screen for or diagnose the condition — that is a clinician's work.
Everything here comes from population-level association records, put together by code. Those records compare groups of people; they do not examine anyone, and they give no guidance on care. For symptoms, testing or treatment, ask a clinician.
What a 23andMe/AncestryDNA export or raw VCF can and can't tell you about Fibromyalgia comes down to these specific, well-studied positions — not a diagnosis.
Databases, guidelines and references
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Fibromyalgia. MyGeneLog™. https://www.mygenelog.com/conditions/fibromyalgia
In the GWAS Catalog, Fibromyalgia is filed as "Fibromyalgia". Rather than define it, this page lists the genome-wide findings: 6 positions from 2 studies, each with its study's sample and citation.
Genes play a part: 6 positions have been linked to it, the largest study recording 2,563,755 individuals (European ancestry, African ancestry, South Asian ancestry, Hispanic or Latin American ancestry). But each is a common variant of small effect, and a link found across a population does not cause the condition in any one person.
The catalogue maps the positions to 6 genes: FBLN7, CNNM2, SPATS1, DRD2, TANK-AS1, LINC02607. These are where the positions sit, not proof of how they act.
No. Each variant shifts the odds only slightly, and only on average across many people. No guideline predicts Fibromyalgia from a genotype; a clinician diagnoses it.
Free to reuse. This page's text is original writing from freely-available research, licensed CC BY 4.0 — reuse it, including commercially, with attribution to MyGeneLog™. It's general research-derived information, not medical advice or a diagnosis — see Terms of Use.