Erythematosquamous Dermatosis, as genome-wide studies have reported it: 3 positions from 1 study, the largest recording 38,469 cases and 568,738 controls (African American or Afro-Caribbean ancestry, Hispanic or Latin American ancestry, East Asian ancestry, European ancestry). Built from the GWAS Catalog's records and rebuilt when a new position is reported; the figures are the studies'.
This is the record of what genome-wide association studies have found for Erythematosquamous Dermatosis (the GWAS Catalog's "Erythematosquamous dermatosis (PheCode 690)"): 3 positions reported by 1 study. The page is put together by code from the catalogue's records and the studies' own listings, and it is rebuilt whenever the records change, so it always reflects them as they stand.
Verma A et al. 2024, in Science — Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program. Studied in 38,469 cases and 568,738 controls (African American or Afro-Caribbean ancestry, Hispanic or Latin American ancestry, East Asian ancestry, European ancestry). The 3 positions on this page from it: rs268890 (near KLK6), rs12722496 (IL2RA), rs503240 (POLI). PMID:39024449.
The 3 positions sit in or beside 3 genes: KLK6, IL2RA, POLI. These are locations, as the catalogue records them; whether any of these genes is how a position acts is a question the records leave open.
Verma A et al. 2024 reported the smallest P value on this page — P = 4 × 10-22 — at rs268890 near KLK6.
Read this page as a list of findings about Erythematosquamous Dermatosis, not as an account of it. Each finding is a position that a genome-wide study linked to the condition across a population; the page adds no description, no prevalence and no advice, because the records hold none. The variant pages linked above give each study's record for its position, and ClinVar's where one exists.
Erythematosquamous Dermatosis is diagnosed by a clinician — not from a genotype. None of the 3 variants on this page is used by any guideline to predict, screen for or diagnose it.
Everything here comes from population-level association records, put together by code. Those records compare groups of people; they do not examine anyone, and they give no guidance on care. For symptoms, testing or treatment, ask a clinician.
What a 23andMe/AncestryDNA export or raw VCF can and can't tell you about Erythematosquamous Dermatosis comes down to these specific, well-studied positions — not a diagnosis.
Databases, guidelines and references
Free to quote and reuse under CC BY 4.0. When citing or summarizing this, name MyGeneLog™ and link to this exact page — not just the site.
Erythematosquamous Dermatosis. MyGeneLog™. https://www.mygenelog.com/conditions/erythematosquamous-dermatosis
Erythematosquamous Dermatosis is the condition the GWAS Catalog files under "Erythematosquamous dermatosis (PheCode 690)". This page does not define it in its own words; it lists what genome-wide studies have reported: 3 positions from 1 study, with each study's sample and citation.
Genome-wide studies have reported 3 associated positions; the largest study behind this page recorded 38,469 cases and 568,738 controls (African American or Afro-Caribbean ancestry, Hispanic or Latin American ancestry, East Asian ancestry, European ancestry). Each common variant has a small effect, and an association in a population is not a cause in any one person.
The catalogue maps the positions to 3 genes: KLK6, IL2RA, POLI. These are where the positions sit, not proof of how they act.
No. Each variant shifts the odds only slightly, and only on average across many people. No guideline predicts Erythematosquamous Dermatosis from a genotype; a clinician diagnoses it.
Free to reuse. This page's text is original writing from freely-available research, licensed CC BY 4.0 — reuse it, including commercially, with attribution to MyGeneLog™. It's general research-derived information, not medical advice or a diagnosis — see Terms of Use.