Duodenal Ulcer, as genome-wide studies have reported it: 5 positions from 2 studies, the largest recording 17,117 cases and 867,208 controls (Japanese ancestry, European ancestry). Every figure comes from the studies themselves, gathered by code from the GWAS Catalog and updated as the records grow.
This is the record of what genome-wide association studies have found for Duodenal Ulcer (the GWAS Catalog's "Duodenal ulcer (PheCode 531.3)"): 5 positions reported by 2 studies. The page is put together by code from the catalogue's records and the studies' own listings, and it is rebuilt whenever the records change, so it always reflects them as they stand.
Verma A et al. 2024, in Science — Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program. Sample in the catalogue's record: 3,339 cases and 624,535 controls (African American or Afro-Caribbean ancestry, European ancestry, Hispanic or Latin American ancestry). It contributes 4 positions: rs573784774 (UBE2V1P4), rs557100015 (near LINC01492), rs573250197 (CYP2A7P2), rs551365214 (near ACTG1P19). PMID:39024449.
He Y et al. 2023, in Nature Genetics — East Asian-specific and cross-ancestry genome-wide meta-analyses provide mechanistic insights into peptic ulcer disease. Sample in the catalogue's record: 17,117 cases and 867,208 controls (Japanese ancestry, European ancestry). The one position on this page from it: rs3019776 (TPCN2). PMID:38036781.
The catalogue maps the 5 positions to 5 genes: UBE2V1P4, LINC01492, CYP2A7P2, ACTG1P19, TPCN2. That mapping says where a position sits, in a gene or beside one — not what it does. For what each study measured, follow its citation above.
Verma A et al. 2024 reported the smallest P value on this page — P = 2 × 10-14 — at rs573784774 in UBE2V1P4.
It is a record of what genome-wide studies have reported about Duodenal Ulcer, kept current by code. It is not a description of the condition, an estimate of how common it is, or guidance of any kind — a page that took those from association records would be inventing them. Each variant page linked here carries that study's own record for the position in fixed sentences, and ClinVar's record where one exists.
Nothing on this page diagnoses Duodenal Ulcer. The 5 variants here are research findings; no guideline uses them to predict, screen for or diagnose the condition — that is a clinician's work.
Everything here comes from population-level association records, put together by code. Those records compare groups of people; they do not examine anyone, and they give no guidance on care. For symptoms, testing or treatment, ask a clinician.
What a 23andMe/AncestryDNA export or raw VCF can and can't tell you about Duodenal Ulcer comes down to these specific, well-studied positions — not a diagnosis.
Databases, guidelines and references
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Duodenal Ulcer. MyGeneLog™. https://www.mygenelog.com/conditions/duodenal-ulcer
In the GWAS Catalog, Duodenal Ulcer is filed as "Duodenal ulcer (PheCode 531.3)". Rather than define it, this page lists the genome-wide findings: 5 positions from 2 studies, each with its study's sample and citation.
Genome-wide studies have reported 5 associated positions; the largest study behind this page recorded 17,117 cases and 867,208 controls (Japanese ancestry, European ancestry). Each common variant has a small effect, and an association in a population is not a cause in any one person.
The positions lie in or near 5 genes: UBE2V1P4, LINC01492, CYP2A7P2, ACTG1P19, TPCN2. A mapped gene is the catalogue's location for a position, not a mechanism.
No. They are population-level findings of small effect. Duodenal Ulcer is diagnosed by a clinician, and no guideline uses a genotype to predict it.
Free to reuse. This page's text is original writing from freely-available research, licensed CC BY 4.0 — reuse it, including commercially, with attribution to MyGeneLog™. It's general research-derived information, not medical advice or a diagnosis — see Terms of Use.