Costochondritis, as genome-wide studies have reported it: 5 positions from 1 study, the largest recording 902 cases and 567,630 controls (African American or Afro-Caribbean ancestry, European ancestry). Assembled by code from the GWAS Catalog's records and kept current as positions arrive; every figure is the studies' own.
1 study in the GWAS Catalog report 5 positions for Costochondritis, which the catalogue files as "Costochondritis (PheCode 733.6)". MyGeneLog follows the condition as positions arrive: code builds this page from the records, adds each new position when it is reported, and writes no sentence of its own beyond them.
Verma A et al. 2024, in Science — Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program. The catalogue records its sample as 902 cases and 567,630 controls (African American or Afro-Caribbean ancestry, European ancestry). From it, 5 positions on this page: rs528594155 (LINC01828), rs185321370 (near LINC02241), rs572556229 (GLYATL1), rs566994112 (LEMD3), rs541526631 (ABCC4). PMID:39024449.
The catalogue maps the 5 positions to 5 genes: LINC01828, LINC02241, GLYATL1, LEMD3, ABCC4. That mapping says where a position sits, in a gene or beside one — not what it does. For what each study measured, follow its citation above.
Verma A et al. 2024 reported the smallest P value on this page — P = 3 × 10-13 — at rs528594155 in LINC01828.
Association records say which positions differ, on average, between people with Costochondritis and people without. They do not describe the condition, say how common it is, or tell anyone what to do, so this page does not either. For a single position, open its variant page: it gives that study's record in fixed sentences, with ClinVar's where there is one.
Nothing on this page diagnoses Costochondritis. The 5 variants here are research findings; no guideline uses them to predict, screen for or diagnose the condition — that is a clinician's work.
Everything here comes from population-level association records, put together by code. Those records compare groups of people; they do not examine anyone, and they give no guidance on care. For symptoms, testing or treatment, ask a clinician.
What a 23andMe/AncestryDNA export or raw VCF can and can't tell you about Costochondritis comes down to these specific, well-studied positions — not a diagnosis.
Databases, guidelines and references
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Costochondritis. MyGeneLog™. https://www.mygenelog.com/conditions/costochondritis
In the GWAS Catalog, Costochondritis is filed as "Costochondritis (PheCode 733.6)". Rather than define it, this page lists the genome-wide findings: 5 positions from 1 study, each with its study's sample and citation.
Genome-wide studies have reported 5 associated positions; the largest study behind this page recorded 902 cases and 567,630 controls (African American or Afro-Caribbean ancestry, European ancestry). Each common variant has a small effect, and an association in a population is not a cause in any one person.
The positions lie in or near 5 genes: LINC01828, LINC02241, GLYATL1, LEMD3, ABCC4. A mapped gene is the catalogue's location for a position, not a mechanism.
No. Each variant shifts the odds only slightly, and only on average across many people. No guideline predicts Costochondritis from a genotype; a clinician diagnoses it.
Free to reuse. This page's text is original writing from freely-available research, licensed CC BY 4.0 — reuse it, including commercially, with attribution to MyGeneLog™. It's general research-derived information, not medical advice or a diagnosis — see Terms of Use.