Chronic Inflammatory Sinonasal Disease, as genome-wide studies have reported it: 2 positions from 1 study, the largest recording 19,901 cases and 199,208 controls. Assembled by code from the GWAS Catalog's records and kept current as positions arrive; every figure is the studies' own.
This is the record of what genome-wide association studies have found for Chronic Inflammatory Sinonasal Disease (the GWAS Catalog's "Chronic inflammatory sinonasal disease"): 2 positions reported by 1 study. The page is put together by code from the catalogue's records and the studies' own listings, and it is rebuilt whenever the records change, so it always reflects them as they stand.
Saarentaus EC et al. 2023, in Nature Communications — Inflammatory and infectious upper respiratory diseases associate with 41 genomic loci and type 2 inflammation. Sample in the catalogue's record: 19,901 cases and 199,208 controls. It contributes 2 positions: rs6884870 (WDR36), rs1663680 (near LINC02676). PMID:36653354.
The 2 positions sit in or beside 2 genes: WDR36, LINC02676. These are locations, as the catalogue records them; whether any of these genes is how a position acts is a question the records leave open.
The strongest association in the records is rs6884870 in WDR36, reported by Saarentaus EC et al. 2023 at P = 10-22, with an odds ratio of 1.13.
It is a record of what genome-wide studies have reported about Chronic Inflammatory Sinonasal Disease, kept current by code. It is not a description of the condition, an estimate of how common it is, or guidance of any kind — a page that took those from association records would be inventing them. Each variant page linked here carries that study's own record for the position in fixed sentences, and ClinVar's record where one exists.
Chronic Inflammatory Sinonasal Disease is diagnosed by a clinician — not from a genotype. None of the 2 variants on this page is used by any guideline to predict, screen for or diagnose it.
Everything here comes from population-level association records, put together by code. Those records compare groups of people; they do not examine anyone, and they give no guidance on care. For symptoms, testing or treatment, ask a clinician.
What a 23andMe/AncestryDNA export or raw VCF can and can't tell you about Chronic Inflammatory Sinonasal Disease comes down to these specific, well-studied positions — not a diagnosis.
Databases, guidelines and references
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Chronic Inflammatory Sinonasal Disease. MyGeneLog™. https://www.mygenelog.com/conditions/chronic-inflammatory-sinonasal-disease
In the GWAS Catalog, Chronic Inflammatory Sinonasal Disease is filed as "Chronic inflammatory sinonasal disease". Rather than define it, this page lists the genome-wide findings: 2 positions from 1 study, each with its study's sample and citation.
Genes play a part: 2 positions have been linked to it, the largest study recording 19,901 cases and 199,208 controls. But each is a common variant of small effect, and a link found across a population does not cause the condition in any one person.
The catalogue maps the positions to 2 genes: WDR36, LINC02676. These are where the positions sit, not proof of how they act.
No. Each variant shifts the odds only slightly, and only on average across many people. No guideline predicts Chronic Inflammatory Sinonasal Disease from a genotype; a clinician diagnoses it.
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